Blood
Articles in this Issue
A comprehensive genetic study of classic Hodgkin lymphoma using circulating tumor DNA
Abstract This study analyzed the genetics of classic Hodgkin lymphoma (cHL) by using circulating tumor DNA (ctDNA). Two genetic subtypes were identified, differing in genetic instabi...
An in vivo barcoded CRISPR-Cas9 screen identifies <i>Ncoa4-</i>mediated ferritinophagy as a dependence in <i>Tet2</i>-deficient hematopoiesis
Abstract TET2 is among the most commonly mutated genes in both clonal hematopoiesis and myeloid malignancies; thus, the ability to identify selective dependencies in TET2-deficient c...
Breaking ribosomes to fight leukemia
Clinical and molecular features of immunodeficiency in patients with telomere biology disorders
Abstract Immunodeficiency in telomere biology disorders (TBDs) has been described in pediatric patients with severe phenotypes, but is less characterized within the broader TBD spect...
Phase 1/2 trial of anti-CD7 allogeneic WU-CART-007 for patients with relapsed/refractory T-cell malignancies
Abstract Relapsed/refractory T-cell acute lymphoblastic leukemia (ALL; T-ALL)/lymphoma (LBL) represent a significant unmet medical need. WU-CART-007 is a CD7-targeting, allogeneic, f...
A multiomic analysis of Waldenström macroglobulinemia defines distinct disease subtypes
Abstract We carried out a single-cell multiomic analysis on a series of MYD88-mutated Waldenström macroglobulinemia (WM) patients and identified 2 distinct subtypes of disease, memor...
Riding the RhoA rodeo: the role of Myo9b in neutrophils
Immunodeficiency in TBDs: making the lymphocyte count
Targeting ferritinophagy to iron out <i>Tet2</i>-mutant cells
Distinct molecular subtypes in Waldenström macroglobulinemia
Posttranscriptional depletion of ribosome biogenesis factors engenders therapeutic vulnerabilities in <i>NPM1</i>-mutant AML
Abstract NPM1 is a multifunctional phosphoprotein with key roles in ribosome biogenesis among its many functions. NPM1 gene mutations drive 30% of acute myeloid leukemia (AML) cases....
CART-007: a license to kill
Classic Hodgkin lymphoma: the journey over the destination
Visualizing amyloidosis: the role of radionuclide imaging in systemic amyloidosis
Abstract Hematologists have a significant role in the diagnosis and management of light-chain amyloidosis and are frequently involved in the diagnosis of transthyretin and other more...
RhoA GAP Myo9b regulates β2-integrin activity and neutrophil recruitment during murine acute kidney injury
Abstract An acute inflammatory response to infection or sterile injury involves an adequate activation and recruitment of leukocytes. Activation of β2-integrins is required for neutr...