Blood
Articles in this Issue
Large-scale dependency and drug screens to characterize the therapeutic vulnerabilities of multiple myeloma with 1q+
Abstract The development of targeted therapy for patients with multiple myeloma (MM) is hampered by the low frequency of actionable genetic abnormalities. Gain or amplification of ch...
Check the brakes on IRF4!
Interferon-γ sparks inflammatory fire in Castleman disease
Are we ready for an MRD-driven approach in multiple myeloma?
Therapy-related juvenile myelomonocytic leukemia
Isatuximab, carfilzomib, lenalidomide, and dexamethasone induction in newly diagnosed myeloma: analysis of the MIDAS trial
Abstract For patients with transplant-eligible newly diagnosed multiple myeloma, induction therapy with a quadruplet regimen before autologous transplant is the standard of care. The...
How I treat Wiskott-Aldrich syndrome
Abstract Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder, characterized by thrombocytopenia, eczema, recurrent infections, autoimmunity, and malignancy. Here, we discuss c...
A novel mouse model of hemoglobin SC disease reveals mechanisms underlying beneficial effects of hydroxyurea
Abstract Sickle cell hemoglobin C (HbSC) disease results from compound heterozygosity of hemoglobin S (HbS) and hemoglobin C (HbC), comprising 30% of sickle cell disease (SCD). HbC i...
Metabolic pathways in deep vein thrombosis: a new frontier for therapeutic intervention
Abstract Venous thromboembolism, which includes deep vein thrombosis (DVT) and pulmonary embolism, is a common cardiovascular disorder associated with significant morbidity and morta...
HbSC gets its mouse model 75 years after discovery
Another 1q bites the dust
Loss of BCL7A permits IRF4 transcriptional activity and cellular growth in multiple myeloma
Abstract Multiple myeloma (MM) is a complex hematological malignancy characterized by genomic changes and transcriptomic dysregulation. Initial exome sequencing approaches have faile...
IFN-γ promotes the progression of iMCD by activating inflammatory monocytes
Abstract A deeper understanding of the immune landscape in patients with idiopathic multicentric Castleman disease (iMCD) is essential to establish early prognostic stratification an...
Tracking <i>clusterin</i> expression in hematopoietic stem cells reveals their heterogeneous composition across the life span
Abstract Hematopoietic stem cells (HSCs) exhibit significant age-related phenotypic and functional alterations. Although single-cell technologies have elucidated age-related composit...
<i>Clusterin</i>(g) and decoding HSC aging
<i>DNMT3A</i> mutations are unlikely to affect interferon alfa treatment outcomes in patients with polycythemia vera
Abstract DNMT3A mutations in patients with polycythemia vera were heterogeneous and not enriched in interferon alfa–treated patients. DNMT3A mutations had no detectable impact on the...
Cell-autonomous dysregulation of interferon signaling drives clonal expansion of <i>SRSF2</i>-mutant MDS stem/progenitor cells
Abstract Myelodysplastic syndromes (MDSs) are myeloid malignancies often driven by mutations in genes encoding splicing factors (SFs). How these mutations drive the clonal expansion...