Blood
Articles in this Issue
Shomali W. An adaptive survival prediction model in CMML. <i>Blood.</i> 2025;146(7):775-777.
Clinical presentation, management, and outcome of TIAN in CNS lymphoma treated with CD19-CAR T-cell therapy
Abstract Tumor inflammation-associated neurotoxicity (TIAN) was recently proposed as a unique complication of immunotherapy in patients with brain tumor. Here, we report a first comp...
CD99 promotes self-renewal in hematopoietic stem cells and leukemia stem cells by regulating protein synthesis
Abstract Blood production is sustained by hematopoietic stem cells (HSCs), which are typically the only blood cells capable of long-term self-renewal. HSCs exhibit and depend on low...
Safety and efficacy of elranatamab in patients with relapsed and/or refractory immunoglobulin light-chain amyloidosis
Abstract Immunoglobulin light-chain (AL) amyloidosis is a plasma cell disorder characterized by progressive organ dysfunction secondary to deposition of organized immunoglobulin ligh...
Acute myeloid leukemia mimicking mature lymphoid morphology
Shaping individualized care for women with hemophilia A
CD99 tunes translation to sustain stem cells
BCMA: BeCoMing a new hope for AL amyloidosis
Remestemcel-L-rknd (Ryoncil): the first approved cellular therapy for steroid-refractory acute GVHD
Abstract Until recently, the JAK1/2 inhibitor ruxolitinib (Jakafi) was the only therapy for steroid-refractory acute graft-versus-host disease approved by the US Food and Drug Admini...
Casein kinase 1α essentially regulates thrombopoiesis by driving megakaryocyte maturation and cytoskeleton organization
Abstract Throughout thrombopoiesis megakaryocytes (MKs) form proplatelets within the bone marrow (BM) and release platelets into BM sinusoids. Casein kinase 1α (CK1α) is a major play...
LocaTIAN, locaTIAN, locaTIAN
How many NOTCHes (activation pathways) are there in CLL?
Impaired cytotoxic function and exhausted phenotype of natural killer cells in VEXAS syndrome
Abstract VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is an autoinflammatory disorder caused by acquired somatic ubiquitin like modifier activating enzym...
Gene variants influence the response to desmopressin
NK cell exhaustion in VEXAS: another piece in the puzzle
<i>F8</i> gene variants influence the response to desmopressin in hemophilia A carriers
Abstract Desmopressin (DDAVP) is often administered to correct factor VIII (FVIII) levels in female hemophilia A carriers (HACs). However, the post-DDAVP FVIII pharmacokinetic profil...
A noncoding mutation in the <i>NOTCH1</i> gene initiates oncogenic NOTCH signaling via wild-type NICD stabilization in CLL
Abstract Chronic lymphocytic leukemia (CLL) is the most common chronic blood cancer in adults. Active NOTCH signaling in CLL is associated with poorer prognosis. Importantly, patient...
A precision medicine approach to the myelodysplastic syndrome with isolated deletion 5q, 50 years after its discovery
Abstract In 1974, Van den Berghe et al described a distinct hematologic disorder associated with acquired, interstitial deletion of part of the long arm of chromosome 5. This conditi...
Of mice, men, and megakaryocytes: CK1α governs thrombopoiesis
The interleukin-33 receptor (ST2) is a novel therapeutic target to attenuate the progression of hemophilic arthropathy
Abstract Hemophilia A is an X-linked bleeding disorder caused by a blood clotting protein factor VIII deficiency. Patients with hemophilia develop recurrent bleeding episodes. When b...