Blood
Articles in this Issue
ML-DS 2018 TRIAL
Multiselective RAS(ON) inhibition targets oncogenic RAS and overcomes RAS-mediated resistance to FLT3i and BCL2i in AML
Abstract Aberrant activation of RAS/MAPK signaling limits the clinical efficacy of several targeted therapies in acute myeloid leukemia (AML). In FMS-like tyrosine kinase-3 (FLT3)-...
Duffy-null reference ranges for improved clinical care
A small step yet one giant leap for cGVHD biomarkers
High-risk genomic consensus validation for patients with newly diagnosed multiple myeloma using next-generation sequencing
Abstract The prognostic heterogeneity of multiple myeloma is mainly driven by the genomic features of myeloma cells. The International Myeloma Society (IMS)/International Myeloma W...
Distinct biological subtypes of chronic GVHD after pediatric hematopoietic cell transplantation
Abstract Chronic graft-versus-host-disease (cGVHD) is the primary nonrelapse limitation to a successful hematopoietic cell transplantation and is largely treated as a single biolog...
CPX-351 in Down syndrome–associated myeloid leukemia: results and prognostic factors from the phase 3 ML-DS 2018 trial
Abstract Myeloid leukemia of Down syndrome (ML-DS) is associated with an excellent prognosis but high treatment-related toxicity and mortality. The Phase 3 Clinical Trial for CPX-3...
Elevated serum erythropoietin level in JAK2+ polycythemia vera with small vessel Budd-Chiari syndrome
Patient-reported outcomes: a Polaris for POLARIX
miR-aculous effects for hemophilic arthropathy
PROs vs clinician-reported adverse events in a large clinical trial: findings from the phase 3 POLARIX study
Abstract Diffuse large B-cell lymphoma (DLBCL) poses a challenge in hematology given its varied symptoms, and the complex interplay between disease and treatment effects on health-...
Multinational assessment of absolute neutrophil counts and white blood cell counts among healthy Duffy-null adults
Abstract Laboratory reference intervals must reflect population diversity for accurate medical decisions. The Duffy-null variant lowers absolute neutrophil counts (ANC), but existi...
Factor VIIa–released extracellular vesicles attenuate joint bleed–induced hemophilic arthropathy
Abstract Repeated bleeding into joints in hemophilia leads to chronic inflammation that plays a central role in the pathogenesis of hemophilic arthropathy (HA). Our recent studies...
Resistance is not futile: RAS inhibition resensitizes AML
Time to say adieu to FISH in myeloma diagnostics
Prior transplantation and idecabtagene vicleucel in multiple myeloma: a secondary analysis of CIBMTR data
Abstract Recent analyses have suggested a possible negative impact of prior autologous stem cell transplantation on outcomes with idecabtagene vicleucel (ide-cel) chimeric antigen...