Blood
Articles in this Issue
Diagnosis-to-treatment interval is associated with outcomes in follicular lymphoma treated with immunochemotherapy
Abstract A short diagnosis-to-treatment interval independently predicts inferior outcomes in follicular lymphoma. Using international discovery and validation cohorts, we demonstra...
Beijing, Baltimore, or both: a randomized draw
CD49d: beyond a prognostic marker in CLL
Albumin-derived pseudo-Dutcher bodies in nonsecretory myeloma
Iron in HSCs: too much of a good thing
A randomized trial of GVHD prophylaxis in haploidentical PBSC transplantation: ATG, PTCy, and low-dose combination therapy
Abstract The optimal graft-versus-host disease (GVHD) prophylaxis strategy in haploidentical peripheral blood stem cell transplantation remains controversial. In this open-label, p...
Sutimlimab vs B-cell–targeted therapy in cold agglutinin disease: which is the optimal approach?
Abstract Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia caused by monoclonal immunoglobulin M autoantibodies that bind to red blood cells and trigger hemolysis...
Genotype-immunophenotype relationships in <i>NPM1</i> -mutated AML clonal evolution uncovered by single-cell multiomic analysis
Abstract Acute myeloid leukemia (AML) is a multiclonal disease, existing as a milieu of clones with unique but related genotypes as initiating clones acquire subsequent mutations....
IRF2 is an essential transcription factor with pathogenic and prognostic impact in multiple myeloma
Abstract Multiple myeloma (MM), the second most prevalent hematologic malignancy, remains incurable, highlighting the need to identify molecular drivers of disease progression and...
From bench to broken brains: freeze-dried platelets
Single-cell tracking of the fittest in AML
In search of dependencies in myeloma, consider IRF2 too
CD49d governs immune synapse formation through actin rearrangements and synchronizes BCR signaling in CLL
Abstract B-cell receptor (BCR) signaling is a key determinant of chronic lymphocytic leukemia (CLL) pathophysiology. CD49d, the α4 subunit of the very late antigen 4 integrin, can...
A dried platelet–derived biologic for blood-brain barrier repair and hemorrhage control after TBI in mice
Abstract Traumatic brain injury (TBI) is the leading cause of death in children and adults aged 1 to 44 years. Despite its high prevalence and devastating consequences, there are c...
Anti–HPA-1a fetal-neonatal alloimmune thrombocytopenia: reframing diagnostics, pathophysiology, and management
Abstract Maternal alloantibodies directed to human platelet antigen 1a (HPA-1a) on fetal platelets can induce fetal-neonatal alloimmune thrombocytopenia (FNAIT), which causes intra...
Iron overload damages mitochondria and induces metabolic rewiring of hematopoietic stem cells toward glycolysis
Abstract Iron is an essential element for most cellular processes, and recent evidence highlighted its role in regulating the function of hematopoietic stem cells (HSCs). Abnormal...