Blood
Articles in this Issue
Real-world incidence of bleeding events in patients with chronic lymphocytic leukemia treated with acalabrutinib +/- obinutuzumab and requiring direct oral anticoagulation
Abstract Background: A significant proportion of patients (pts) with Chronic Lymphocytic Leukemia (CLL) have cardiovascular comorbidities re...
Inclusive practices for safe and equitable donor assessment
Abstract Background: Guidance is needed to optimize the recruitment, verification typing (VT) and workup of donors from vulnerable populatio...
PI3 kinase inhibition reduces CAR T cell trogocytosis mediated fratricide
Abstract Chimeric antigen receptor (CAR) T cell mediated trogocytosis (CMT) involves the transfer of the CAR binding antigen to the surface...
Time toxicity in ALL: Quantifying home days among adults with acute lymphoblastic leukemia
Abstract Background: Treatment-related time toxicity, the burden of time to receive medical care, is increasingly recognized as an important...
Should dermatologic examinations become routine standard of care in patients with polycythemia vera? Observations from the phase 3 VERIFY study prior to rusfertide exposure
Abstract Background: Patients with polycythemia vera (PV) are at increased risk of developing other non-PV malignancies, including skin canc...
Effect of graft cellular content on outcomes in HLA mismatched hematopoietic cell transplantation using post-transplant cyclophosphamide
Abstract Background Since the introduction of post-transplant cyclophosphamide (PTCY) for graft versus host disease (GVHD) prophylaxis, the...
A multifunctional nanoplatform for ferroptosis inducing/chemo/photothermal therapy enhances therapeutic effect and prevents adverse gastrointestinal reaction of methotrexate
Abstract Backgrounds: Methotrexate (MTX) is pivotal in treating aggressive lymphomas. Recent studies show MTX not only interferes with DNA s...
Improved long-term tolerability with asciminib (ASC) vs investigator-selected (IS) tyrosine kinase inhibitors (TKIs) in patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP): Week 96 exploratory analysis of the phase 3 ASC4FIRST trial
Abstract Introduction Long-term CML treatment (Tx) requires assessing adverse event (AE) burden over time to optimize safety, tolerability,...
Machine learning models improve survival prediction in DLBCL: Analysis from the goya trial
Abstract Background: The International Prognostic Index (IPI) remains widely used for risk stratification in diffuse large B-cell lymphoma (D...
LDB1-dependent enhancer networks drive high-risk transcriptional programs in T-cell acute lymphoblastic leukemia
Abstract In T-cell acute lymphoblastic leukemia (T-ALL), LMO2 (Lim domain only 2) is frequently overexpressed due to chromosomal translocati...
Hetrombopag for the treatment of lower-risk myelodysplastic syndromes with thrombocytopenia: A prospective, single-arm, multicenter study
Abstract Background: Myelodysplastic syndromes (MDS) are a group of clonal myeloid disorders characterized by ineffective hematopoiesis, per...
A real-world experience of axicabtagene ciloleucel CAR-T in refractory/relapsed B-cell lymphoma from a tertiary center in Saudi Arabia
Abstract Introduction: Axicabtagene ciloleucel (axi-cel) is an autologous anti-CD19 CAR T-cell therapy approved for the treatment of relapse...
Unravelling molecular determinants of ruxolitinib treatment response in myelofibrosis using single cell multiomics
Abstract Myelofibrosis (MF) originates from the acquisition of somatic mutations in hematopoietic stem and progenitor cells (HSPCs). MF driv...
The ‘αO2-PRBCThal’ trial on the use of hemanext One® for blood transfusion support transfusion-dependent thalassemia
Abstract Introduction: Patients with transfusion dependent thalassemia (TDT) are regularly transfused every two to four weeks. Red blood cel...
BRM/BRG1 is a novel therapeutic target in ZNF384-rearranged mixed phenotype acute leukemia
Abstract Mixed Phenotype Acute Leukemia (MPAL) is an understudied high-risk leukemia with poor outcomes. Patients have been historically exc...
Cost-effectiveness of hydroxyurea for children with sickle cell disease in sub-saharan Africa: A discrete event simulation model to inform policy and government planning
Abstract Background Sickle cell disease (SCD) is a highly common inherited disorder affecting more than 500,000 infants born each year, prim...
CLL with t(11;14)(q13;q32) or t(14:18)(q32:q21) – is this CLL or lymphoma?
Abstract Background: The IGH rearrangements resulting from t(11;14)(q13;q32) and t(14;18)(q32;q21) typically characteriz...
Acquired FVIII deficiency in the setting of prior mechanical mitral valve replacement: A delicate balance of competing hemorrhagic and thrombotic risks
Abstract Introduction: Acquired Factor VIII (FVIII) deficiency, also known as acquired hemophilia A, is a rare and letha...
Age-related differences in presentation among pediatric, adolescent, and young adults with mixed cellularity vs. nodular sclerosis histology Hodgkin lymphoma on Children's oncology group treatment and registry trials
Abstract Introduction: Classic Hodgkin lymphoma (HL) is one of the most common cancers in adolescents and young adults (AYA; 15-39 years [y]...
A new validated staging system for AL amyloidosis with stage IIIc defining an ultra-poor prognostic in systemic AL amyloidosis in the modern treatment era
Abstract Background: Systemic AL amyloidosis is an incurable disorder caused by misfolded light chain fibrils. Survival is determined by the...
Organ-based classification and risk-stratified outcomes in 568 east Asian patients with chronic active epstein-barr virus infection: A multicenter retrospective cohort study
Abstract Background: Chronic active Epstein-Barr virus infection (CAEBV) is a rare and potentially fatal lymphoproliferative disorder charac...
Diagnostic delays and misdiagnosis patterns in paroxysmal nocturnal hemoglobinuria
Abstract Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematopoietic stem cell disorder characterized by complement-mediat...
Mortality trends and disparities in purpura and related hemorrhagic conditions in the elderly population in the United States from 1999 to 2023: A CDC wonder databaseanalysis
Abstract Introduction: Purpura and related hemorrhagic conditions are a spectrum of bleeding disorders consisting of various types of purpur...
Achieving JAK2V617F vaf <20% is associated with prolonged event-free survival in polycythemia vera: A milestone of molecular response
Abstract Background:In chronic myeloid leukemia (CML), absolute BCR-ABL molecular thresholds serve as validated milestones to predict long-t...
MYC rearrangements with immunoglobulin genes as an independent prognostic factor of progression-free survival in newly diagnosed patients
Abstract Introduction: MYC rearrangement (MYC-R), especially those involving the immunoglobulin loci (IGL, IGH, and IGK), are drivers of MM...