Blood
Articles in this Issue
It takes two to tango: <i>Enterococcus</i> boosts epithelial MHC-II
Ronceray L, Huibers MHW, Reutter K, et al. High-grade/large B-cell lymphoma-11q has a very good prognosis in children and young people without a predisposition. <i>Blood.</i> 2026;147(2):209-214.
Beyond ATP: asciminib and the allosteric path in CML
DNA methylation matters: methylation of the γ-globin ( <i>HBG</i> ) gene promoters is required for postnatal silencing of HbF
Abstract Sufficient levels of fetal hemoglobin (HbF) can ameliorate the pathophysiologic basis of sickle cell disease and β-thalassemia postnatally. DNA methylation has long been p...
Silencing of BCL11A by disrupting enhancer-dependent epigenetic insulation
Abstract The transcription factor BCL11A is a genetically and clinically validated regulator of the fetal-to-adult hemoglobin switch in human erythroid cells. CRISPR editing of an...
NLRP3 inflammasome blockade treats intestinal inflammation associated with chronic granulomatous disease
Abstract Chronic granulomatous disease (CGD) is an inborn error of immunity associated with a 50% prevalence of inflammatory bowel disease (IBD) for which current treatments are su...
Uncovering the genomic complexity of <i>PAX5</i> intragenic tandem multiplication via long-read and short-read sequencing
Abstract By integrating short-read whole-genome sequencing and RNA sequencing (RNA-seq) data with long-read RNA-seq, we dissect the complex genomic architecture of PAX5 intragenic...
Targeting enhancer RNAs to silence transcription
Comprehensive molecular and functional analysis of <i>NUTM1</i> -rearranged leukemia
Abstract NUTM1 rearrangement defines a significant subset of B-cell acute lymphoblastic leukemia (B-ALL), particularly in infants lacking KMT2A rearrangements, yet its underlying m...
Time to revise myeloma diagnostic criteria? A decade of accumulated evidence on a serum free light chain ratio of ≥100
Abstract In 2014, the International Myeloma Working Group (IMWG) expanded multiple myeloma diagnostic criteria to include a serum free light chain (sFLC) ratio of ≥100 as a standal...
Asciminib demonstrates superior efficacy and safety in newly diagnosed chronic myeloid leukemia in the ASC4FIRST trial
Abstract Many patients receiving frontline tyrosine kinase inhibitors (TKIs) for chronic-phase chronic myeloid leukemia (CML-CP) experience inadequate disease control and/or advers...
Benchmarking clonal hematopoiesis in sickle cell disease
Ketones and the NLRP3 inflammasome: you are what you eat
Increased prevalence of clonal hematopoiesis in children with sickle cell disease
Abstract Recent studies have reached opposing conclusions about whether clonal hematopoiesis (CH) is increased or decreased in patients with sickle cell disease (SCD). Given that C...
Jaye DL, Feldman AL. ALK-negative anaplastic large cell lymphoma with <i>JAK2</i> rearrangement mimicking classic Hodgkin lymphoma. <i>Blood</i> . 2023;141(17):2160.
Cracking the nut of <i>NUTM1</i> rearrangements in infant leukemia
Myelodysplastic CMML-1 mimicking ITP, unmasked by corticosteroids: evolution from clonal monocytosis
Evolution of multiple myeloma from a genomic perspective
Abstract In this review, we explore the role of complex interactions between genomic evolution, environmental and genetic predispositions, and immune surveillance in disease progre...
<i>Enterococcus faecalis</i> induces MHC-II expression by the intestinal epithelium during murine graft-versus-host disease
Abstract Intestinal Enterococcus domination has been associated with an increased risk of mortality from acute graft-versus-host disease (GVHD) after allogeneic hematopoietic cell...