Blood
Articles in this Issue
Competition for CD19 binding may accelerate CAR efficacy
Deficiency of neutrophil gelatinase-associated lipocalin elicits a hemophilia-like bleeding and clotting disorder in mice
Abstract Coagulation is related to inflammation, but the key pathway, especially innate immune system and coagulation regulation, is not well understood and need to be further explor...
Targeted interferon therapy with modakafusp alfa for relapsed or refractory multiple myeloma
Abstract Interferon alfa has activity against multiple myeloma (MM). Modakafusp alfa is an immunocytokine comprising 2 attenuated interferon alfa-2b molecules and an anti-CD38 immuno...
Monitoring CH: time to move beyond VAF?
Novel treatment strategies for chronic myeloid leukemia
Abstract Starting with imatinib, tyrosine kinase inhibitors (TKIs) have turned chronic myeloid leukemia (CML) from a lethal blood cancer into a chronic condition. As patients with ac...
Hypercalcemia in MGUS: keep the differential diagnosis broad
NGAL: a new link between thrombosis and hemostasis
Introduction to a series of reflections on a quarter century of TKIs for CML
This Review Series highlights the transformative impact of tyrosine kinase inhibitors (TKIs) on therapy for chronic myeloid leukemia (CML) in the last 25 years. Brian J. Druker introduces the series b...
Anti-CD19 antibody cotreatment enhances serial killing activity of anti-CD19 CAR-T/-NK cells and reduces trogocytosis
Abstract Anti-CD19 chimeric antigen receptor (CAR)–engineered T and natural killer (NK) cell therapies have revolutionized the treatment of B-cell malignancies, but challenges includ...
Long-term outcomes of tyrosine kinase inhibitors in chronic myeloid leukemia
Abstract Long-term outcomes with tyrosine kinase inhibitors (TKIs) show that their impact on chronic myeloid leukemia (CML) is sustained as shown by 13 studies with 5- to 14-year-fol...
Novel interferon-based antimyeloma activity
Approaching hypercalcemia in monoclonal gammopathy of undetermined significance: insights from the iStopMM screening study
Abstract Hypercalcemia in monoclonal gammopathy of undetermined significance (MGUS) presents a clinical challenge because it may indicate progression to multiple myeloma (MM) but cou...
The evolution of treatment-free remission
Abstract One of the most remarkable achievements of the tyrosine kinase inhibitor (TKI) era has been the capacity to induce deep molecular remissions that are sustainable off therapy...
Distinctive morphologic finding of multifocal perifollicular concentric granulomas in a lymph node with IgG4 plasmacytosis
Methylation sequencing enhances interpretation of clonal hematopoiesis dynamics
Abstract We have developed a cost-effective DNA methylation sequencing assay to improve monitoring of clonal hematopoiesis. By inferring cell-type proportions, this method enhances i...