Blood
Articles in this Issue
New insights into trauma: TG2 and fibrin cross-linking
Targeting STK17B kinase activates ferroptosis and suppresses drug resistance in multiple myeloma
Abstract The progression of multiple myeloma (MM), an incurable malignancy of plasma cells, is often associated with the suppression of ferroptosis, a type of cell death driven by...
STK10 emerges from the platelet kinome shadow
How blasts get into the skin—and how to get rid of them
Fetal defense against leukemia: a developmental shield
Genomic determinants of response and resistance to pirtobrutinib in relapsed/refractory chronic lymphocytic leukemia
Abstract Pirtobrutinib, a noncovalent, reversible Bruton tyrosine kinase inhibitor (BTKi), demonstrated efficacy in patients with chronic lymphocytic leukemia (CLL), resistant to c...
<i>Blood</i> : flowing stronger than ever after 80 years
Mechanisms of immune escape and extramedullary tropism in leukemia cutis
Abstract The mechanisms that lead to extramedullary tropism of acute myeloid leukemia (eAML) remain obscure and no specific therapeutic approaches for this entity exist. Because th...
Fetal context conveys heritable protection against MLL-rearranged AML that depends on MLL3
Abstract MLL rearrangements (MLLrs) are the most common cause of congenital and infant leukemias. MLLrs arise prior to birth and can transform fetal/neonatal progenitors with the h...
Targeting STK17B: unlocking ferroptosis in myeloma
Measurable residual disease intervention in AML: a new therapeutic horizon
Abstract Acute myeloid leukemia (AML) is a polyclonal malignancy marked by high relapse rates despite initial morphologic remission. Although measurable residual disease (MRD) is a...
Tissue transglutaminase drives fibrin β-chain cross-linking: a novel fibrin modification observed in patients with trauma
Abstract Covalent cross-linking of fibrin by the plasma transglutaminase coagulation factor XIII (FXIII) is a key determinant of blood clot stability and function. FXIII-catalyzed...
Pal R, Janz M, Galson DL, et al. C/EBPβ regulates transcription factors critical for proliferation and survival of multiple myeloma cells. <i>Blood</i> . 2009;114(18):3890-3898.
Shifting clones: CLL evolution under pirtobrutinib treatment
STK10 regulates platelet function in arterial thrombosis and thromboinflammation
Abstract Serine/threonine kinase 10 (STK10) is a member of the Ste20 family of serine/threonine kinases and regulates lymphocyte adhesion. Quantitative phosphoproteomic assay showe...