Blood
Articles in this Issue
Circulating tumor cells in myeloma are a compound biomarker for bone marrow high-risk genomic alterations and tumor load
Abstract High levels of circulating tumor cells (CTC) are a powerful predictor of poor outcomes in newly diagnosed multiple myeloma, yet the mechanistic underpinnings of this corre...
What's in a name? HLH/hyperinflammatory syndromes
Advancing the classification of hematolymphoid neoplasms together: for patients, medicine, and science
Abstract A single, universally used tumor classification system is critical to ensure precision in patient care, clinical trial enrollment, and advancing therapy. Since the publica...
Platelet defects in patients and mice with Ehlers-Danlos syndrome
Abstract Ehlers-Danlos syndrome (EDS) is a group of connective tissue disorders characterized by joint hypermobility, skin hyperelasticity, perivascular tissue fragility, easy brui...
CD38+ monocytes fuel fibrosis in myeloproliferative neoplasm
From nothing to abundance for hemophilia with inhibitors
Slowing the cell cycle to increase fetal hemoglobin
CXCL9 as a novel prognostic marker to identify high-risk adults with hemophagocytic lymphohistiocytosis
Abstract Hemophagocytic lymphohistiocytosis (HLH) is an interferon gamma–driven hyperinflammatory syndrome with high morbidity and mortality. Identifying reliable prognostic biomar...
Efficacy and safety of marstacimab prophylaxis in hemophilia A/B with inhibitors: results from the phase 3 BASIS trial
Abstract Marstacimab, a monoclonal antibody that inhibits tissue factor pathway inhibitor, is approved for prophylactic use in individuals with hemophilia A or B without inhibitors...
At a crossroads: circulating tumor cells in myeloma
EDS: from Hippocrates to hyporeactive platelets
The role of CD38 in monocytes during fibrotic progression of myeloproliferative neoplasms
Abstract Proinflammatory signaling is a hallmark of myeloproliferative neoplasms. Several studies have shown that monocytes are a major source of proinflammatory cytokines and that...
CD25+ mast cell hyperplasia in myeloid/lymphoid neoplasm with <i>PDGFRA</i> rearrangement mimicking systemic mastocytosis
p27Kip1 regulates γ-globin production
Abstract Sickle cell disease (SCD) and β-thalassemia are devastating genetic disorders resulting from defects in the β-globin subunit of adult hemoglobin. Both disorders are amelio...
Somatic genetic rescue in <i>ZCCHC8</i> -associated telomere biology disorders
Abstract We show that somatic genetic rescue is frequent in telomere biology disorders (TBDs) caused by germ line ZCCHC8 variants. Our results highlight the critical intrinsic role...