Blood
Articles in this Issue
Tri-specific autologous CD19.20.22 chimeric antigen receptor (CAR) T-cells for patients with Relapsed/Refractory B-cell lymphomas.
Abstract Introduction: CD19-directed CAR T cell (CAR-T) therapy has curative potential for patients with relapsed/refractory (R/R) B-cell ly...
Role of anti-GP antibodies release with platelet-derived extracellular vesicles in regulating ITP platelet apoptosis
Abstract Anti-glycoprotein(GP) antibodies-mediated platelet destruction has been recognized as the most typical pathogenesis of ITP. Our pre...
External validation of the intermountain risk scores for post-discharge (PD) thrombosis and bleeding in an independent population
Abstract Introduction: Extended pharmacologic thromboprophylaxis in medical patients has largely failed to demonstrate clinical benefit in m...
Intronic DNA variants in EZH2 and GATA2 predict treatment-free remission in chronic myeloid leukemia patients from the destiny trial
Abstract Background: Chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors (TKIs) have excellent survival outcomes...
Talquetamab alters T cell transcriptome in presence of GPRC5D on MM cells
Abstract Background: G protein-coupled receptor class C group 5 member D (GPRC5D) has emerged as an important immune tar...
Results of the APG2575AU101 Study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax–exposed myeloid malignancies
Abstract Introduction Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) have poor prognoses. Venetoclax plus hypomethylating...
Distinguishing on-target efficacy and off-target toxicity with antibody drug conjugates (ADCs) on diseased and normal hematopoietic cells
Abstract One of the challenges with ADC treatment is off-target toxicity to hematopoietic cells resulting in neutropenia, severe anemia and...
Field-level visual explanations for leukocyte classification using AI model: Enhancing interpretability in peripheral smear diagnostics
Abstract Introduction Despite notable advances in deep learning, the clinical integration of artificial intelligence (AI...
Real-world outcome of low-frequency outpatient monitoring for venetoclax initiation in CLL: Single-center experience
Abstract Background: The treatment landscape for CLL/SLL has shifted from chemoimmunotherapy to targeted therapies, with BCL-2 inhibitors li...
Risk of venous thromboembolism associated with CDK 4/6 inhibitors and adjuvant hormonal therapy in non-metastatic breast cancer: A systematic review and meta-analysis
Abstract Background: Hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), non-metastatic breast cance...
Outcome disparities among survivors of hematologic malignancies diagnosed in childhood
Abstract Introduction: Latinos are a rapidly growing population in the Southwest U.S. Evidence has suggested population-based differences in...
Inhibition of DOCK1 prevents the clonal expansion of high-risk TP53-mutant clonal hematopoiesis induced by genotoxic stressors.
Abstract Background: TP53-mutant clonal hematopoiesis (CH) is prevalent in populations that received genotoxic cancer therapy and is associa...
Multi-endpoint AI morphology model (MEAM) enhances risk prediction for vascular events and disease progression in MPNs
Abstract INTRODUCTION The myeloproliferative neoplasms (MPNs) are clonal haematological disorders that display significa...
Blood tells a hidden story: Von willebrand disease in the puzzle of refractory postpartum hemorrhage
Abstract Blood Tells a Hidden Story: Revealed Von Willebrand Disease in the Puzzle of Refractory Postpartum Hemorrhage Nasim Salimiaghdam1,...
Retrospective real-world data analysis of morbidity burden and healthcare costs in idiopathic multicentric castleman disease compared with matched controls (BURDEN-iMCD)
Abstract Introduction: Idiopathic multicentric Castleman disease (iMCD) is a rare, cytokine-driven hematologic disorder characterized by dif...
Genomic and immune determinants of response to CD3 x CD20 bispecific antibodies in aggressive B-cell lymphoma
Abstract Introduction: CD3 x CD20 bispecific antibodies (BsAb)have been approved for use in relapsed/refractory (R/R) diffuse large B-cell ly...
Frontline therapy patterns and outcomes in chronic lymphocytic leukemia: A real-world, multicenter analysis from Latin America.
Abstract Background: Access to novel therapies for chronic lymphocytic leukemia (CLL) varies throughout Latin America. M...
National trends and disparities in AL amyloidosis-related mortality among multiple myeloma patients in the United States: A population-based study (1999–2023)
Abstract Background: Immunoglobulin light chain (AL) amyloidosis is a multisystem disorder resulting from the deposition of misfolded monocl...
The preliminary results of MRG001-C002: A phase II Study of MRG001 combined with Orelabrutinib in patients with relapsed or refractory diffuse large B-cell lymphoma (R/R DLBCL)
Abstract Background: Patients (pts) with R/R DLBCL who failed with multi-agent therapy have a poor prognosis. MRG001 is a CD20-directed anti...
The silent foe: Agranulocytosis-related mortality in the United States from 1999 to 2023: Insights from the CDC wonder database
Abstract The Silent Foe: Agranulocytosis-Related Mortality in the United States from 1999 to 2023: Insights from the CDC Wonder Database Int...
Trial in progress: Phase I trial to evaluate safety of oral azacytidine in combination with pomalidomide as maintenance therapy in AML
Abstract Background and Significance: Despite achieving complete remission with induction therapy, approximately 60% of...
Risk of bleeding in chronic lymphocytic leukemia patients in remission treated with covalent Bruton tyrosine kinase inhibitors and contemporary anticoagulant or antiplatelet drugs: Real-world data analysis
Abstract Introduction: Covalent Bruton tyrosine kinase inhibitors (BTKis) have revolutionized the treatment of chronic lymphocytic leukemia...
Mortality trends in chronic myeloid leukemia in the United States: A population-based analysis
Abstract Introduction Chronic Myeloid Leukemia (CML) accounts for roughly 15% of the newly diagnosed adult leukemias. Prognosis has improved...
Subtotal versus total splenectomy in children with sickle cell disease: Clinical outcomes and splenic function assessed by pocked red blood cell count
Abstract Background: The spleen is one of the first organs affected by sickle cell disease (SCD). While splenectomy may be indicated in some...
Role of genetic testing in diagnosing patients with severe congenital neutropenia: Results from PATH4WARD genetic testing program
Abstract Patients with suspected severe congenital neutropenia (SCN) frequently exhibit a wide spectrum of clinical manifestations, which ca...