Blood
Articles in this Issue
High-grade/large B-cell lymphoma-11q has a very good prognosis in children and young people without a predisposition
Abstract High-grade B-cell lymphoma with 11q aberration (HGBCL-11q) is a rare pediatric non-Hodgkin lymphoma. This study assessed outcome in 90 children with HGBCL-11q. With surviv...
The treatment of marginal zone lymphoma
Abstract The treatment landscape of B-cell non-Hodgkin lymphomas is rapidly evolving. However, few advances have occurred in marginal zone lymphoma (MZL), with a single US Food and...
Off-the-shelf dual CAR-iNKT cell immunotherapy eradicates medullary and leptomeningeal high-risk <i>KMT2A</i> -rearranged leukemia
Abstract Current therapies, including autologous chimeric antigen receptor (CAR) T-cell immunotherapy, fail to cure half of infants with KMT2A-rearranged acute lymphoblastic leukem...
Introduction to a review series on marginal zone lymphoma: reclaiming the afterthought
Marginal zone lymphoma (MZL) is a heterogenous group of indolent B-cell lymphomas, originally grouped together because of similarities in histological and immunophenotypic cellular features and now re...
Jagged2-Notch axis: keeping stem cells in asymmetric balance
Telomere content and genomics of myeloid neoplasia by whole-genome sequencing
Abstract Telomere length shortening has been associated with genomic instability and acquisition of molecular lesions, but these processes have not been systematically studied acro...
A Notch <i>trans-</i> activation to <i>cis</i> -inhibition switch underlies hematopoietic stem cell aging
Abstract Aged hematopoietic stem cells (HSCs) expand in clusters over time, while reducing their regenerative capacity and their ability to preserve the homeostasis of the hematopo...
Bispecific CAR-iNKT cells: beyond dual antigen targeting
Hematopoietic transplantation for PNP deficiency: it’s time
Hematopoietic stem cell transplantation for purine nucleoside phosphorylase deficiency: an EBMT-IEWP retrospective study
Abstract Purine nucleoside phosphorylase (PNP) deficiency causes inadequate purine metabolite detoxification, which leads to combined immunodeficiency and variable neurologic sympt...
Acute promyelocytic leukemia diagnosed on soft tissue biopsy: a rare extramedullary presentation
The biology of marginal zone lymphoma subtypes: challenge and relevance of classification
Abstract Marginal zone lymphomas (MZLs) are a heterogeneous group of low-grade B-cell neoplasms classified into different entities by the current lymphoma classifications. They sha...
Drug development in MZL: caring for the forgotten child
Abstract Marginal zone lymphoma (MZL) comprises a biologically heterogenous group of indolent B-cell lymphomas that remain substantially underrepresented in clinical research. Desp...