Blood
Articles in this Issue
Deep dive into shallow myeloma cell pool
Ultrasensitive detection of circulating multiple myeloma cells by next-generation flow after immunomagnetic enrichment
Abstract The continuous improvement in progression-free survival (PFS) of patients with multiple myeloma (MM) raises interest in evaluating peripheral residual disease (PRD) toward m...
The landscape of disease: mapping aplastic anemia
Checkpoint-primed allo-HCT in HL: cure gains, risk remains
When TNFα is out, IFN-γ drives anemia of inflammation
Cracking the POD24 code in follicular lymphoma
A burden too high for CAR T cells in CLL
Protecting the epithelium and taming GVHD
Outcomes of allogeneic HCT in Hodgkin lymphoma in the era of checkpoint inhibitors: a joint CIBMTR and EBMT analysis
Abstract Checkpoint inhibitors (CPIs) have shown remarkable efficacy in Hodgkin lymphoma (HL), and are now used routinely. While allogeneic hematopoietic cell transplantation (allo-H...
The T follicular helper/T follicular helper regulatory pathway in FVIII immune responses in mice
Abstarct Developing anti–factor VIII (FVIII) inhibitory antibodies (inhibitors) are a significant complication of FVIII protein replacement therapy in hemophilia A. Our previous stud...
CALR-ifying ATF6/BCL-xL activation by type 2 CALR mutations
Type 2 calreticulin mutations activate ATF6 to promote BCL-xL–mediated survival in myeloproliferative neoplasms
Abstract Most calreticulin (CALR) mutations in myeloproliferative neoplasms are classified as either type 1, a 52–base pair deletion (CALRdel52); or type 2, a 5–base pair insertion (...
Challenges in GVHD and GVL after hematopoietic stem cell transplantation for myeloid malignancies
Abstract Although allogeneic hematopoietic stem cell transplantation is a leading treatment approach for myeloid malignancies, challenges in its immune biology and in treatment appro...
TNFα signaling restores steady-state hematopoiesis in a TNFαKO mouse model of anemia of inflammation
Abstract Anemia of inflammation (AI) is the second most common form of anemia and is prevalent in patients with chronic inflammatory states, such as infection, autoimmunity, and canc...
Combined PET and ctDNA response as a predictor of POD24 for follicular lymphoma after first-line induction treatment
Abstract Patients with follicular lymphoma who experience disease progression within 24 months of diagnosis (POD24) have a lower survival. Positron emission tomography (PET) response...
Imaging mass cytometry reveals the order of events in the pathogenesis of immune-mediated aplastic anemia
Abstract The autoimmune response driving hematopoietic stem and progenitor cell (HSPC) destruction in immune-mediated aplastic anemia (AA) remains incompletely understood. We previou...
ZUMA-8: a phase 1 study of brexucabtagene autoleucel in patients with relapsed/refractory chronic lymphocytic leukemia
Abstract ZUMA-8 evaluated the safety of brexucabtagene autoleucel (brexu-cel), a CD19-directed autologous chimeric antigen receptor (CAR) T-cell immunotherapy, for patients with rela...
Allo-HCT in Hodgkin lymphoma after CPI
Phase 1/2 study of high-dose palifermin for GVHD prophylaxis in patients undergoing HLA-matched unrelated donor HCT
Abstract Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic cell transplantation (HCT). Palifermin, a recombinant N-truncated keratinocyte growth fa...