Blood
Articles in this Issue
CaDAnCe-302, a phase 3, open-label, randomized study of BGB-16673 compared with idelalisib + rituximab (R), bendamustine + R, or venetoclax + R re-treatment in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma previously exposed to both a BTK and BCL2 inhibitor
Abstract Introduction: Novel therapies, including Bruton tyrosine kinase (BTK) inhibitors and B-cell lymphoma 2 (BCL2) inhibitors, have mean...
No overall increased risk of death or cardiovascular disease in individuals with sickle cell trait: A prospective study of 467,957 general population adults
Abstract Introduction Sickle cell trait (SCT) is among the most prevalent carrier states on earth. While traditionally considered benign, un...
Causes of death in chronic lymphocytic leukemia/small lymphocytic lymphoma during the novel agent era: A population-based analysis
Abstract Background: Chemoimmunotherapy (CIT) had long been used to treat chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)...
County-level analysis reveals two high-incidence regions and potential environmental contributors to myeloid malignancies in Colorado
Abstract Background: Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are hematologic malignancies that result from an accumu...
Metabolic signatures mirror divergent modalities of leukemia immune evasion and relapse after transplantation
Abstract Acute myeloid leukemia (AML) relapse after allogeneic hematopoietic cell transplantation (allo-HCT) is increasingly recognized as a...
A first-in-human study of CT0596, an allogeneic CAR T-cell therapy targeting BCMA, in patients with relapsed/refractory multiple myeloma
Abstract Introduction Universal CAR T-cell therapy addresses key challenges of autologous CAR T, including high cost, time-consuming, person...
Journey of relapsed or refractory multiple myeloma (RRMM) after quadruple-class exposure (QCEx): Poor outcomes and high attrition
Abstract Introduction: Patients with RRMM who have been exposed to 4 classes of treatment (quadruple-class exposed; QCEx) with proteasome in...
Mapping proteomic signatures in iPSC-derived neutrophils: Modeling neutropenia
Abstract Severe congenital neutropenia (SCN) encompasses a diverse range of genetic defects that impair the differentiation and function of...
Safety characteristics of brentuximab vedotin among patient subgroups: Insightsfrom pooled clinical trial database
Abstract Rationale and background: For the approval of new drug products or label expansions, conducting clinical trials that are fully repr...
Prevalence, clinical implications and impact of stem cell transplantation in UBTF-TD positive AML
Abstract Background: Recurrent tandem duplications (TDs) of upstream binding transcription factor (UBTF) have recently been described in adu...
Germline alterations of hematopoietic growth factor receptors and maladaptive somatic genetic rescue leads to myeloid neoplasia
Abstract Using rationally targeted NGS screen, we have previously identified germ line (GL) alteration in genes linked to hereditary bone ma...
Characteristics and outcomes for patients with concomitant myeloproliferative neoplasms (MPN) and autoimmune disorders
Abstract Introduction Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by dysregulated prolife...
Targeting hedgehog signaling/KL4-dependent M2 macrophage polarization for treatment of chronic graft-versus-host diseases and tissue fibrosis
Abstract Background: Chronic graft-versus-host disease (cGVHD) represents the leading cause of non-relapse-related mortality and morbidity f...
Evaluation of cytarabine consolidation dosing in older adult patients with Acute Myeloid Leukemia
Abstract Introduction: Post remission therapy in patients (pts) with acute myeloid leukemia (AML) who are intensive indu...
National alliance of sickle cell centers consensus recommendations for defining an adult sickle cell disease specialist
Abstract Background Sickle cell disease (SCD) affects at least 100,000 people in the United States (US). Acute pain is the most common reaso...
Diagnostic relevance of SH2B3 mutations in suspected myeloid malignancies: Insights from a large-scale NGS-based screening study
Abstract INTRODUCTION The SH2B3 gene encodes the cytoplasmic adaptor protein LNK that acts as a negative regulator of hematopoietic progenit...
Novel small molecule inhibitors of mitochondrial permeability transition pore (mPTP) block platelet procoagulant activity
Abstract Subpopulations of procoagulant platelets expose phosphatidylserine (PS) on their plasma membrane, providing a catalytic surface for...
Convergence in age adjusted mortality rates and proportion of all deaths from COVID-19 among patients with hematologic malignancies, 2020-2024
Abstract Introduction: Patients with hematologic malignancies (HM) are often immunocompromised, either as a result of their illness or its t...
Comparative evaluation of ipss-m and cpss-mol in CMML: Impact of molecular markers on prognosis
Abstract Introduction Chronic myelomonocytic leukemia (CMML) is a heterogeneous hematologic malignancy with overlapping...
The B2M–LILRB1 axis as a novel myeloid immune checkpoint and therapeutic target in multiple myeloma
Abstract Cancer immunotherapies have shown significant promise in multiple myeloma (MM). However, their long-term efficacy is limited by imm...
Double jeopardy: Heart failure and thrombotic thrombocytopenic purpura in the inpatient setting
Abstract Background: Thrombotic thrombocytopenic purpura (TTP) is a life-threatening microangiopathic disorder requiring urgent intervention...
Comparative effectiveness of emergency department versus pain infusion clinic management for acute pain in adults with sickle cell disease: Implications for cost and timeliness of care
Abstract Background: Acute pain is the most common reason for healthcare utilization among adults living with Sickle Cell Disease (SCD). Whi...
Impact of VEGF inhibition on the development of erythrocytosis in hereditary hemorrhagic telangiectasia
Abstract Introduction In hereditary hemorrhagic telangiectasia (HHT), erythrocytosis is typically attributed to chronic...
Real-world factor VIII trough levels of severe-type people with Hemophilia A (PwHA) on efanesoctocog alfa prophylaxis: Interpersonal variation, clinical correlates and predictors
Abstract Introduction: Efanesoctocog alfa (EA) is a high-sustained FVIII, designed to decouple FVIII from endogenous von Willebrand factor (...
Exploring the relationship between serum iron, patient morbidity, mortality, and length of hospitalization in a burn center
Abstract Iron is ubiquitous within the human body and serves numerous functions. Given its roles in oxygen transport, immune function, and w...