Blood
Articles in this Issue
Azacitidine as therapy for VEXAS syndrome
Immunochemotherapy for older patients with ATLL: a new option?
Introduction to a review series on the structural underpinnings of hemostatic plugs and thrombotic occlusions
Structure and function are the 2 critical knowledge elements that must be combined for complex systems such as occlusive thrombus formation to be understood. Edited by Associate Editor Thomas L. Ortel...
All in one place: the future of blood group typing
Array genotyping of transfusion-relevant blood cell antigens in 6946 ancestrally diverse study participants
Abstract Blood transfusions save millions of lives worldwide each year, yet formation of antibodies against nonself antigens remains a significant problem, particularly in patients...
Dangerous clones with complex ties to AL amyloidosis
Structure and interactions of the proteins from the contact system
Abstract The contact system includes factor XII (FXII), FXI, prekallikrein (PK), and high-molecular-weight kininogen (HK), and has received increased interest as a potential target i...
Structure-based design of therapeutics to control hemostasis
Abstract Hemorrhage causes millions of deaths and hundreds of billions of dollars in medical costs every year, and a large percentage of trauma bleeding–associated deaths occur in th...
Factor XIII: driving (cross-)links in hemostasis, thrombosis, and disease
Abstract Blood clots are complex structures composed of blood cells and proteins held together by a structural framework provided by an insoluble fibrin network. Factor (F)XIII is a...
Platelet activation and signaling in thrombus formation
Abstract In thrombosis and hemostasis, the formation of a platelet-fibrin thrombus or clot is a highly controlled process that varies, depending on the pathological context. Major si...
Loss of DCAF8 impairs hematopoietic stem cell function with cellular senescence via the DOCK11-CDC42 axis
Abstract Hematopoietic stem cells (HSCs) are responsible for sustaining the hematopoietic system throughout life, and their functional decline contributes to hematological disorders...
UPS delivers apolarity and senescence to HSCs
A phase 2 trial of CHOP with anti-CCR4 antibody mogamulizumab for older patients with adult T-cell leukemia/lymphoma
Abstract No standard of care for older patients with aggressive adult T-cell leukemia/lymphoma (ATL) has been established. We evaluated the efficacy of CHOP (cyclophosphamide, doxoru...
Loss of <i>BAP1</i> defines a unique subtype of <i>TP53</i>-mutated de novo AML and confers sensitivity to BCL-xL inhibitors
Abstract Mutations in TP53 are mutually exclusive with other known drivers of myeloid transformation and define a distinct molecular subtype within de novo acute myeloid leukemia (AM...
Exploring the thrombus niche: lessons learned and potential therapeutic opportunities
Abstract Thrombus structure and composition are the main determinants of the severity, course, and outcomes of thrombosis. Detailed thrombus morphology has become available due to me...
<i>BAP1/TP53</i> loss defines a BCL-xL–dependent erythroleukemia
Diverse ancestry genotyping of blood cell antigens
Single-cell and clonal analysis of AL amyloidosis plasma cells and their bone marrow microenvironment
Abstract AL amyloidosis is a disorder characterized by expansion of clonal plasma cells in the bone marrow and distant end organ damage mediated by misfolded immunoglobulin free ligh...
Efficacy and safety of azacitidine for VEXAS syndrome: a large-scale retrospective study from FRENVEX
Abstract VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a severe monogenic disorder caused by somatic mutations in ubiquitin-like modifier activating en...