Blood
Articles in this Issue
Integrin αvβ8–mediated TGF-β1 activation regulates the sustained response in immune thrombocytopenia after TPO-RA withdrawal
Abstract Only 30% to 50% of patients with immune thrombocytopenia (ITP) exhibit a sustained response upon thrombopoietin receptor agonists (TPO-RA) withdrawal, underscoring the nec...
MMF unlocks a new path to venetoclax sensitivity in AML
Guanine nucleotides drive ribosome biogenesis and glycolytic reprogramming in acute myeloid leukemia stem cells
Abstract Therapy resistance in acute myeloid leukemia (AML) remains a major clinical obstacle, particularly because of the persistence of leukemia stem cells (LSC) capable of metab...
Prostaglandins in cancer revisited: principles of production, mechanisms of immune regulation, and therapeutic perspectives
Abstract The cyclooxygenase (COX) signaling pathway is frequently dysregulated in cancer, resulting in the aberrant production of prostaglandins, a distinct class of bioactive lipi...
Follicular lymphoma transformed to classic Hodgkin lymphoma
The ticking clock of relapse in T-cell lymphomas
Phase 2 trial of rituximab with either pentostatin or bendamustine for multiply relapsed or refractory hairy cell leukemia
Abstract The primary objective in multiply relapsed hairy cell leukemia and variant (HCL/HCLv) was to determine whether pentostatin-rituximab (DCFR) and bendamustine-rituximab (BR)...
An old but still good friend: chemoimmunotherapy in HCL
Inflammation perturbs hematopoiesis by remodeling specific compartments of the bone marrow niche
Abstract Hematopoietic stem and progenitor cells are regulated by interactions with stromal cells in the bone marrow (BM) cavity, which can be segregated into 2 spatially defined c...
Stuck on you: Tregs, αvβ8, TGF-β1, and platelets in ITP
Early time to relapse as a survival prognosticator in nodal mature T-cell lymphomas: results from the PETAL consortium
abstract We assessed the overall survival (OS) impact of time to relapse (TTR) in multinational cohorts with independent observational and randomized validation. Patients with nMTC...