Blood
Articles in this Issue
Blood-based proteomic profiling identifies OSMR as a novel biomarker of AML outcomes
Abstract Inflammation is increasingly recognized as a critical factor in acute myeloid leukemia (AML) pathogenesis. We performed blood-based proteomic profiling of 251 inflammatory p...
Socioeconomic factors and transplant access
Disrupting HIT immune complexes as a new treatment for HIT
Genetic challenges in the hole puncher
PI3Kγ in leukemia: class IB PI3 kinase reemerges as a cancer-intrinsic target
Abstract Phosphoinositide 3-kinase gamma (PI3Kγ), the only class IB PI3 kinase, is a cell-extrinsic immunotherapy target in solid tumors. PI3Kγ inhibition reprograms immunosuppressiv...
Prognostic biomarkers in MCL: insights from the SHINE trial on the impact of MCL35 score and <i>TP53</i> mutation status
Abstract The MCL35 gene expression assay encompasses key risk features and stratified older patients with mantle cell lymphoma (MCL) using routine biopsies. In the SHINE trial, high-...
Maternal regulation of iron metabolism resolved?
Precision pre-HSCT conditioning by targeting cMPL
The bone marrow NK-cell profile predicts MRD negativity in patients with multiple myeloma treated with daratumumab-based therapy
Abstract Natural killer (NK) cells are important effector cells in antibody-based immune therapies for multiple myeloma (MM) through antibody-dependent cellular cytotoxicity. Here, w...
OSMR takes the leap: from NULISA to ELISA
Destabilization of PF4-antigenic complexes in heparin-induced thrombocytopenia
Abstract Heparin-induced thrombocytopenia (HIT) is initiated by antibodies that recognize large antigenic complexes composed of multiple molecules of cationic platelet factor 4 (PF4)...
Severe oxidant hemolysis in a child with G6PD deficiency and Hb C trait
cMPL-based purification and depletion of human hematopoietic stem cells: implications for pretransplant conditioning
Abstract The thrombopoietin:cMPL signaling axis is a critical regulator of early hematopoiesis. However, the utility of cMPL as a standalone marker for identifying long-term repopula...
Beyond genotype: challenges in predicting disease risk for carriers of biallelic perforin variants
Abstract Genetic screening for severe congenital immunohematological diseases offers potential for early intervention, particularly through preemptive allogeneic hematopoietic stem c...
How I treat type 1 plasminogen deficiency
Abstract Type 1 plasminogen deficiency (PLGD), an ultrarare disorder caused by PLG pathogenic variants, results in decreased levels of immunoreactive and functional plasminogen. PLGD...
A natural head start to MRD negativity in multiple myeloma
Access to AlloTx for AML: the value of the social phenotype
Safety and efficacy of a fitusiran antithrombin-based dose regimen in people with hemophilia A or B: the ATLAS-OLE study
Abstract Fitusiran, a subcutaneous investigational small interfering RNA therapeutic, lowers antithrombin (AT) to increase thrombin generation and rebalance hemostasis in people wi...
Maternal <i>Tmprss6</i> is required for hepcidin suppression and fetal health
Abstract The antenatal role of the hepcidin-regulating protease Tmprss6 has never been elucidated because knockout dams are infertile. Using an in vivo knockdown approach, we confirm...
Social determinants of health and access to allogeneic hematopoietic cell transplantation for acute myeloid leukemia
Abstract Whether allogeneic hematopoietic cell transplant (allo-HCT) to treat acute myeloid leukemia (AML) is equitably accessible regardless of social determinants of health (SDOH)...