Blood
Articles in this Issue
Losing CD38 in myeloma
Somatic <i>IRF4</i> mutations and thymic tropism in primary mediastinal large B-cell lymphoma
Abstract Disease-defining signatures in lymphomas, driven by intricate molecular mechanisms, have advanced molecular taxonomies, refined classification, and may guide clinical manage...
Deciphering opsonized zymosan–induced phosphorylation of p47phox and NADPH oxidase activation in human neutrophils
Abstract Neutrophils play a key role in innate immunity by killing microbes through phagocytosis and superoxide anion production by the phagocyte reduced NAD phosphate (NADPH) oxidas...
Time to complete remission is an independent determinant of survival after intensive chemotherapy in AML
Abstract The purpose of this study was to explore and determine the optimal landmark for defining complete remission after intensive induction therapy that best correlates with long-...
Karpova D, Huerga Encabo H, Donato E, et al. Clonal hematopoiesis landscape in frequent blood donors. <i>Blood</i> . 2025;145(21):2411-2423.
Clinical significance of preleukemic somatic <i>GATA1</i> mutations in children with Down syndrome
Abstract Children with Down syndrome (DS) have a high risk of GATA1-associated myeloid leukemia (ML-DS) before age 4 years. Somatic N-terminal GATA1 mutations (GATA1s) are necessary,...
Thrombocytopenia in myelofibrosis is characterized by inflammatory megakaryocytes with reduced G6B expression
Abstract The megakaryocytic (MK)-specific immunoreceptor G6b-B plays an essential role in MK development. Because germ line loss-of-function mutations of G6b-B in humans and its dele...
New prognostic systems for multiple myeloma in the context of contemporary therapies
Abstract Recent clinical trials in both transplant-eligible and -ineligible newly diagnosed multiple myeloma using 3- and 4-drug combinations have demonstrated unprecedented levels o...
Epstein-Barr virus sequence mutations cause human diseases
Silent TAM keeps quiet
G6b on the rise (or not?)
Association of Epstein-Barr virus genomic alterations with human pathologies
Abstract Epstein-Barr virus (EBV) infects &gt;90% of humans and is associated with both hematological and epithelial malignancies. Here, we analyzed 990 EBV genomes (319 newly se...
Biallelic antigen escape is a mechanism of resistance to anti-CD38 antibodies in multiple myeloma
Abstract Monoclonal antibodies targeting CD38 are a therapeutic mainstay in multiple myeloma (MM). Although they have contributed to improved outcomes, most patients still experience...
Deciphering the dynamics of histone acetylation and chromatin remodeling in multiple myeloma: a tale beyond the tails
Abstract The development of multiple myeloma is typically associated with various cytogenetic abnormalities; however, these genetic changes alone do not fully account for the observe...