Blood
Articles in this Issue
The endothelial mTORC2-Foxo1 axis serves as an iron-responsive sensor governing systemic iron homeostasis
Abstract Liver sinusoidal endothelial cells (LSECs) are essential for maintaining liver function by actively sensing nutrients and producing angiocrine factors. LSECs also regulate s...
Rebalancing the hemophilia teeter-totter
A new prognostic index (CLIPI) for advanced cutaneous lymphoma enables precise patient risk stratification
Abstract Advanced mycosis fungoides (MF) and Sézary syndrome (SS) have a poor overall survival (OS) of <5 years. Studies have found the current staging (IA-IVB) is inadequate...
How I treat pediatric pulmonary embolism
Abstract Venous thromboembolism (VTE) affects ∼1 in 200 hospitalized children. The diagnosis of pulmonary embolism (PE), the most severe clinical presentation of VTE, has increased d...
AML halts neutrophil maturation
Remission conversion drives outcomes after CAR T-cell therapy for multiple myeloma: a registry analysis from the DRST
Abstract Cellular therapies targeting B-cell maturation antigen have shown promise in controlled clinical trials, but their impact in broader, diverse patient populations remains und...
Marstacimab prophylaxis in hemophilia A/B without inhibitors: results from the phase 3 BASIS trial
Abstract Marstacimab targets the tissue factor pathway inhibitor to rebalance hemostasis. Previous phase 1 and 2 trials established marstacimab safety and efficacy in adults with sev...
Foxo1 unlocks the liver endothelial code to iron sensing
More than skin deep
CAR-DLI for ALL, but not without lymphodepletion
IPSS-M risk and specific sex-associated somatic mutations predict response to ESA therapy in LR-MDS: building a new score
Abstract Acquired somatic mutations are incorporated in the classification and prognosis of myelodysplastic syndromes/neoplasms (MDSs). However, the predictive role of molecular feat...
The acute myeloid leukemia microenvironment impairs neutrophil maturation and function through NF-κB signaling
Abstract Acute myeloid leukemia (AML), an aggressive hematological malignancy, is driven by oncogenic mutations in stem and progenitor cells that give rise to AML blasts. Although th...
In low-risk myelodysplastic syndrome, don’t shoot the <i>STAG2</i>
Matched donor allogeneic CAR-T for adult B-ALL: toxicity, efficacy, repeat dosing, and the importance of lymphodepletion
Abstract We developed an allogeneic matched donor CD19 chimeric antigen receptor (CAR) product (CAR–donor lymphocyte infusion [DLI]) for adult patients with B-cell acute lymphoblasti...