Blood
Articles in this Issue
Haploidentical hematopoietic stem cell transplantation using low-dose alemtuzumab is effective for standard-risk hematological malignancies
Abstract [Background] We have been performing allogeneic hematopoietic stem cell transplantation from haploidentical related donor using ant...
Early intervention for cytokine release syndrome after chimeric antigen receptor T-cell therapy is associated with an increased risk of cytopenias and infections in patients with large B-cell lymphoma
Abstract Introduction: Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS...
Allogeneic CAR-T therapy AVC-201 in AML positive for CD123
Abstract Introduction: CAR-T therapy in AML has been limited by the absence of ideal target antigens, heterogeneity of the disease, and aggre...
Clinical and biological characteristics of autoimmune neutropenia in adults according to the presence of anti-granulocyte antibodies: A multicenter retrospective Study of 79 cases
Abstract Introduction: Autoimmune neutropenia (AIN) is a rare and poorly described condition in adults. It may be associated or not with aut...
Hermansky-pudlak syndrome and prolonged activated partial thromboplastin time
Abstract A patient with a history of oculocutaneous albinism and easy bruising and a family history of the same presented to our health care...
Lived experience of pregnant patients with sickle cell disease: A qualitative study
Abstract Sickle Cell Disease (SCD) is an inherited blood disorder. It is marked by end-organ effects and increased pregnancy complications....
Hypomethylating agent with venetoclax versus hypomethylating agent alone in frontline management of myelodysplastic syndrome - impact of subgroups on clinical outcomes
Abstract Background: Hypomethylating agent (HMA) with venetoclax (VEN) is used in clinical practice for frontline management of patients wit...
Characterizing Hodgkin lymphoma survivors' shared decision making across the care continuum
Abstract Introduction: With multiple stage-based treatment options like systemic treatment alone, combined modality therapy, and immunothera...
Real-world comparison of progression-free and overall survival between idecabtagene vicleucel (ide-cel) and teclistamab in triple-class exposed relapsed/refractory multiple myeloma
Abstract Introduction: Patients with triple-class exposed (TCE) relapsed/refractory multiple myeloma (RRMM) have historically experienced po...
Thrombotic microangiopathy among hospitalized patients: Demographic characteristics, diagnostic trends, and resource use from a national database study
Abstract Introduction Thrombotic microangiopathy (TMA) is an uncommon but serious class of microvascular disorders with the ability to lead t...
Once-weekly carfilzomib (56 mg/m²), pomalidomide, and dexamethasone (K56Pd) in patients with first-relapsed multiple myeloma: a Multicenter, prospective, Real-world evidence from China
Abstract Introduction: Carfilzomib (CFZ) and pomalidomide maintain clinical efficacy in relapsed/refractory multiple myeloma (RRMM). The pha...
No CARs for miles: Geographic disparities in access to multiple myeloma CAR-T therapy
Abstract Introduction Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized treatment for relapsed/refract...
“Suffering in Silence”: Caregiver and medical team experiences on psychosocial screening among pediatric patients with hematologic malignancies
Abstract Background Children diagnosed with hematologic malignancies face physical and psychosocial stressors impacting the entire family. T...
RALLY MF: A phase 2 Study of DISC-0974, an anti-hemojuvelin antibody, in patients with myelofibrosis and anemia
Abstract Background Hepcidin, a central regulator of iron homeostasis, is pathologically elevated in patients with myelo...
A series of cryo-EM structures resolves the mechanisms of how factor VIII binds to membranes and to factor IXa on the membrane surface
Abstract Membranes containing phosphatidylserine are crucial for the assembly of the intrinsic Xase complex of factors VIIIa and IXa at the...
Risk of mental health outcomes and peak risk periods post-hematologic cancer diagnosis in the United States
Abstract Background: Approximately 40% of persons will develop cancer in their lifetime and a considerable proportion of these individuals w...
Determinants of response of the BCMA/GPRC5D-dual-targeting T-cell redirecting trispecific antibody JNJ-5322 in multiple myeloma
Abstract Introduction BCMA- and GPRC5D-targeting bispecific antibodies (BsAbs) have shown unprecedented clinical efficacy in patients with he...
Plasmablastic lymphoma (PBL) comparison between europe - Latin America and validation of the PBL international prognostic index (PBL-IPI): Collaborative study of the lymphoma groups geltamo, gatla and gell
Abstract Background: Plasmablastic lymphoma (PBL) is a rare and aggressive disease, and data on outcomes from large series are limited. A pr...
A tale of two settings: Survival disparities in CLL/SLL between academic and community cancer programs in the u.S. national cancer database
Abstract Background: Hematologic malignancies are managed at both academic and community-based centers. Studies across solid tumors and bloo...
Evolving use of blast percentage thresholds and classification systems in AML clinical trials (2022–2025): A data-driven trend analysis
Abstract Background: The diagnostic threshold for acute myeloid leukemia (AML) has evolved significantly across classification systems over...
SL0439: A structure-tuned bispecific nanobody CAR-T cells targeting BCMA/GPRC5D for relapsed/refractory multiple myeloma with extramedullary disease
Abstract Background: Despite B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell therapies...
A diagnostic pitfall: Therapy-related acute promyelocytic leukemia mimicking mixed-phenotype acute leukemia
Abstract Acute myeloid leukemia (AML) is a heterogeneous group of diseases characterized by distinct genetic alterations. The acute promyelo...
Systematic intensification of red cell exchange with hydroxyurea decreased the transfusion burden in patients with sickle cell disease: A single-center retrospective cohort study
Abstract Sickle cell disease (SCD) is a common and severe inherited hemoglobinopathy affecting millions worldwide. This chronic condition le...
National trends and demographic disparities in mortality due to bleeding disorders in the u.S., 1999–2020
Abstract Background: Bleeding disorders encompass a diverse group of conditions, from inherited hemophilia to acquired coagulopathies like D...
Analysis of efficacy and prognostic factors in transfusion-dependent thalassemia following allogeneic hematopoietic stem cell transplantation using the ‘gx-07-tm’ regimen
Abstract Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only curative treatment for transfusion-dependent...