Blood
Articles in this Issue
Glutathionylated leaky mitochondrial pores as target in AML
De novo CD19− B-ALL: awareness of a rare entity in initial diagnosis
Incremental changes to improve outcomes in ALL
Dysbiosis and gastrointestinal GVHD: to treat or not to treat
Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation
Abstract Patients with acute myeloid leukemia (AML) have a poor 5-year survival rate, highlighting the need for the identification of new approaches to target this disease. AML is...
The conundrum of drug development in higher-risk MDS: lessons learned from recently failed phase 3 clinical trials
Abstract Aside from allogeneic transplantation, the current standard-of-care approach for higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) remains monotherapy with a hypome...
Mucosal calprotectin is associated with severity of aGI-GVHD and poor outcomes after allogeneic stem cell transplantation
Abstract Calprotectin, a calcium- and zinc-binding protein that comprises the subunits S100A8 and S100A9, has been extensively studied as a biomarker of gastrointestinal (GI) infla...
Thrombosis risk model for critically ill children
Age-adapted chemotherapy and MRD-oriented transplant for Ph-negative acute lymphoblastic leukemia: the GRAALL-2014 trial
Abstract The Group for Research in Adult Acute Lymphoblastic Leukemia (GRAALL)-2014 trial evaluated an intensive, age-adapted protocol for adults aged 18 to 59 years with Philadelp...
Withaferin A inhibits EBV-driven lymphomagenesis through multiple mechanisms, including EBNA1 degradation
Abstract Epstein-Barr virus (EBV) infects over 90% of the global population and drives multiple aggressive B-cell malignancies, including Burkitt lymphoma, diffuse large B-cell lym...
Utility of peripheral blood testing for detection and surveillance of clonal hematopoiesis in predisposed individuals
Abstract In this study, 108 pediatric patients with bone marrow (BM) failure and leukemia predisposition were evaluated for presence of clonal hematopoiesis in peripheral blood (PB...
One ball, two hits
Ramantamig (JNJ-79635322), a novel T-cell-engaging trispecific antibody targeting BCMA, GPRC5D, and CD3, in multiple myeloma models
Abstract In multiple myeloma (MM), cell-specific antigens are valuable targets for developing effective T-cell-engaging therapeutics that can provide good immune responses. Achievi...
Multisite validation of a venous thrombosis risk model in critically ill children through the CHAT Consortium
Abstract Critically ill children are at a high risk for hospital-associated venous thromboembolism (HA-VTE). Developing a validated risk assessment model (RAM) to identify children...