Blood
Articles in this Issue
Paradoxical urban mortality penalty in sickle cell disease: A 20-year national analysis revealing age-dependent disparities
Abstract Background: Advancements in sickle-cell disease (SCD) management have improved care for ~100,000 affected Americans. However, morta...
Socioeconomic disadvantage, as measured by area deprivation index (ADI), impacts survival in patients with relapsed/refractory aggressive lymphoma treated with CART
Abstract Background: Socioeconomic disadvantage, as measured by the Area Deprivation Index (ADI), is associated with adverse health outcomes...
Optimal ferritin threshold to diagnose immune effector cell-associated hemophagocytic syndrome (IEC-HS) following CAR-T therapy in relapsed/refractory multiple myeloma (RRMM)
Abstract Background: IEC-HS is a potentially life-threatening complication following CAR-T therapy in RRMM. Reliable diagnostic biomarkers a...
Emergency presentation worsens survival, complications, and reveals profound disparities in acute lymphoblastic leukemia: A national propensity-matched study
Abstract Background Acute lymphoblastic leukemia (ALL) can progress rapidly and often presents with nonspecific symptoms, leading to delays...
Summary analysis of the phase 1a/b study with HBI0101, an academic anti-BCMA chimeric antigen receptor T-cell (CART) for relapsed/refractory multiple myeloma
Abstract BACKGROUND: Although anti-B-cell maturation antigen (BCMA) chimeric antigen receptor T-cell (CART) therapy showed unprecedented eff...
Accounting for long-term survivors and population-expected survival improves survival outcomes estimation and prediction in older patients with core-binding factor (CBF) Acute Myeloid Leukemia (AML)
Abstract Introduction While disease-related features such as recurrent genetic abnormalities are routinely used to inform patient (pt) progn...
HDAC inhibitors potentiate the efficacy of antineoplastic agents in acute megakaryoblastic leukemia via dual activation of apoptosis and pyroptosis
Abstract Background Acute megakaryoblastic leukemia (AMKL), a high-risk pediatric AML subtype (FAB-M7), carries a partic...
Clinical efficacy of allogeneic hematopoietic stem cell transplantation in infant acute leukemia
Abstract Introduction Infant leukemia, including AML and ALL occurring within the first year of life, is a rare and aggressive disease with...
Carfilzomib, lenalidomide, and dexamethasone (KRd) versus bortezomib, lenalidomide and dexamethasone (VRd) in patients with newly diagnosed multiple myeloma (NDMM) – interim results from the randomized Phase III COBRA trial.
Abstract Background: VRd-based regimens are currently the standard for the frontline treatment in NDMM. KRd and KRd-based regimens show high...
Real-world disease burden and treatment patterns among triple-class–exposed patients with relapsed/refractory multiple myeloma and extramedullary disease in the US: A retrospective analysis using Flatiron Health electronic medical records
Abstract Introduction:Patients (pts) with triple-class exposed (TCE; exposure to ≥1 proteasome inhibitor [PI], ≥1 immunomodulatory drug [IMi...
Trust and relationships between people with sickle cell disease and healthcare professionals: Regional comparisons from the listen survey
Abstract Background and Aim Sickle cell disease (SCD) significantly impacts health, with care quality influenced by healthcare professionals...
Rapid genomic analysis for the early identification of complement abnormalities in adults with transplant associated thrombotic microangiopathy
Abstract Background Transplant-associated thrombotic microangiopathy (TA-TMA) is a rare but often fatal complication of allogeneic hematopoi...
Prognostic impact of mixed chimerism with undetectable measurable residual disease in pediatric and adolescent young adult patients undergoing allogeneic hematopoietic stem cell transplantation for hematological malignancies
Abstract Background Mixed chimerism (MC), defined as <95% donor chimerism post-allogeneic HSCT, has traditionally been associated wit...
Melatonin, wnt and S1P signaling regulate diurnal bone marrow mesenchymal stem cell metabolism, cell size and function
Abstract Mesenchymal stem cells (MSC) are critical components of the bone marrow (BM) niche, essential for maintaining the hematopoietic ste...
Enhancing joint and bone health outcome in Hemophilia A by protein S inhibition
Abstract Background: Hemophilia A (HA) is a genetic disorder caused by deficient coagulation factor VIII, leading to impaired clotting. Curr...
Outcomes of urgent inpatient chemotherapy for relapsed/refractory multiple myeloma in the modern era
Abstract Introduction: Patients (pts) with relapsed/refractory (R/R) multiple myeloma (MM) often receive urgent chemotherapy (chemo) in the...
Outcomes and risk factors of second allogeneic hematopoietic stem cell transplantation in patients with relapsed hematological malignancy after first transplantation
Abstract Introduction The therapeutic utility of a second allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains uncertain i...
Asynchronous acquisition of hematopoietic stem cell (HSC) quiescence, regenerative potential, and immune competence during neonatal maturation
Abstract Background: Neonatal sepsis remains a leading cause of infant mortality and is driven in part by the functional immaturity of the h...
Venous thromboembolism in multiple myeloma patients treated with BCMA-directed CAR T-cell therapy: A systematic review and meta-analysis
Abstract Background. Multiple myeloma (MM) ia associated with a 7–9-fold higher risk of venous thromboembolism (VTE) than the general popula...
Clinical outcomes in hospitalized sickle cell patients with palliative care consults
Abstract Introduction The use of palliative care in patients with sickle disease has been largely understudied. The rese...
Immune restoration in long-term myeloma survival revealed by single-cell RNA-sequencing
Abstract Background: Multiple myeloma (MM) remains incurable despite advances in modern therapies. A small subset of patients achieves long-...
Synergistic integration of CAR-T cell pharmacokinetics and NGS-MRD evolution enables precision risk stratification in relapsed/refractory B-cell acute lymphoblastic leukemia
Abstract Background: Predicting long-term treatment response to CAR-T therapy for R/R B-ALL remains a major challenge, making it difficult t...
Sequential CD19 and CD22 CART for relapsed and refractory B cell ALL: Phase I results
Abstract Background Relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) is a predominantly CD19+/CD22+ hematologic maligna...
Supporting routine diagnostics: AI for interpretation of interphase FISH images
Abstract Introduction: Fluorescence in situ hybridization (FISH) is a valuable method for quick analysis of relevant cop...
Factors associated with central nervous system relapse after b-acute lymphoblastic leukemia: A Children's oncology group report
Abstract Introduction: While advancements in treatment of pediatric B-cell acute lymphoblastic leukemia (B-ALL), through incorporation of no...