Blood
Articles in this Issue
CD24 senescent neutrophils as key players in myelofibrosis
Defective neutrophil clearance in <i>JAK2</i> <i>V617F</i> myeloproliferative neoplasms drives myelofibrosis via immune checkpoint CD24
Abstract Myeloproliferative neoplasms (MPNs) are hematopoietic stem cell–driven malignancies marked by excessive myelopoiesis and high risk of myelofibrosis, which remains therapeuti...
Cracking TRALI: targeting the membrane attack complex
Not dead yet: GWAS insights into a common bleeding disorder
Counterpoint: the design and interpretation of blood transfusion randomized clinical trials
Abstract A recent Perspective in Blood suggested that previous evidence from over a decade ago established that a liberal rather than a restrictive blood transfusion strategy results...
Keep your distance or lose control
Van Laer C, Lavend’homme R, Baert S, et al. Functional assessment of genetic variants in thrombomodulin detected in patients with bleeding and thrombosis. <i>Blood</i>. 2025;145(17):1929-1942.
Optimal MRD-based end point to support response-adapted treatment cessation in newly diagnosed multiple myeloma
Abstract The therapeutic success of first-line quadruplet (QUAD) induction therapy and autologous stem cell transplantation (ASCT) has reinvigorated an interest in fixed-duration the...
Inhibition of terminal complement complex formation alleviates murine antibody-mediated TRALI
Abstract Transfusion-related acute lung injury (TRALI) is a leading cause of blood transfusion–triggered mortality. Recently, we demonstrated the critical role of Fc-dependent comple...
Atypical cytoplasmic inclusions and erythrophagocytosis in acute myeloid leukemia with <i>KMT2A</i>::<i>MLLT3</i> and <i>U2AF1</i> mutation
Genome-wide meta-analysis of heavy menstrual bleeding reveals 36 risk loci
Abstract Heavy menstrual bleeding (HMB) is a widespread occurrence among women of reproductive age and inflicts a substantial impact on their well-being and on health care expenses....
Sustained MRD negativity: robust, not all-powerful
Reactivation of developmentally silenced globin genes through forced linear recruitment of remote enhancers
Abstract The human genome contains regulatory DNA elements, known as enhancers, that can activate gene transcription over long chromosomal distances. Here, we showed that enhancer di...
Daratumumab-bortezomib-thalidomide-dexamethasone for newly diagnosed myeloma: CASSIOPEIA minimal residual disease results
Abstract Previous results from CASSIOPEIA demonstrated superior progression-free survival (PFS) and minimal residual disease (MRD) negativity with the addition of daratumumab to bort...
Speeding up for lympho-myeloid differentiation
Myeloma: a sky full of MRD stars
How I treat acute lymphoblastic leukemia in the era of immunotherapy while revisiting the myth of second remission
Abstract In 2013, we published a Perspective titled “The myth of the second remission of acute leukemia in the adult,” which underscored the dismal outcomes of relapsed acute leukemi...
Coordinated regulation of self-renewal and cell cycle during human lympho-myeloid lineage restriction
Abstract Recent studies indicate the human lympho-myeloid restriction process to be a different and more heterogeneous one than historically inferred. Here we describe the developmen...