Blood
Articles in this Issue
Cullin-5 controls the number of megakaryocyte-committed stem cells to prevent thrombocytosis in mice
Abstract Cullin-5 (Cul5) coordinates the assembly of cullin-RING-E3 ubiquitin ligase complexes that include the suppressors of cytokine signaling (SOCS)-box–containing proteins. The...
Nanobody-based naturally selected CD7-targeted CAR-T therapy for acute myeloid leukemia
Abstract Approximately 30% of patients with acute myeloid leukemia (AML) express CD7 on their myeloblasts. We have previously demonstrated that single-chain variable fragment (scFv)–...
Prolymphocytic progression of splenic marginal zone lymphoma
Therapy for MYD88 L265P DLBCL
Air pollution is associated with increased risk of venous thromboembolism: the Multi-Ethnic Study of Atherosclerosis
Abstract Air pollution exposure may induce procoagulant effects, and chronic exposure may be linked to greater risk of venous thromboembolism (VTE). We tested the hypothesis that air...
Lasalocid A selectively induces the degradation of MYD88 in lymphomas harboring the MYD88 L265P mutation
Abstract Myeloid differentiation primary response protein 88 (MYD88) is a key adaptor molecule in the signaling pathways of toll-like receptor and interleukin-1 receptor. A somatic m...
Mutations in <i>AMBRA1</i> aggravate β-thalassemia by impairing autophagy-mediated clearance of free α-globin
Abstract Accumulation of free α-globin is a critical factor in the pathogenesis of β-thalassemia. Autophagy plays a crucial role in clearing toxic free α-globin, thereby reducing dis...
Childhood Langerhans cell histiocytosis hematological involvement: severity associated with <i>BRAF</i> <i>V600E</i> loads
Abstract Hematological involvement (HI) is one of the life-threatening risk organs (ROs) in Langerhans cell histiocytosis (LCH). Lahey criteria have defined HI since 1975 as hemoglob...
Over 4 decades, French children teach about LCH
The contribution of the monocyte-macrophage lineage to immunotherapy outcomes
Abstract Macrophages execute core functions in maintaining tissue homeostasis, in which their extensive plasticity permits a spectrum of functions from tissue remodeling to immune de...
ALK+ anaplastic large cell lymphoma expressing CD33 and myeloid nuclear differentiation antigen
Cullin’ the herd: Cul5 limits megakaryocyte-biased HSCs
Air pollution and venous thromboembolism
CD7 CAR-T: a bridge to transplant in AML
AMBRA1 performs a balancing act in β-thalassemia
Novel mechanisms of resistance in CLL: variant BTK mutations in second-generation and noncovalent BTK inhibitors
Abstract Bruton tyrosine kinase inhibitors (BTKis) are an established standard of care in chronic lymphocytic leukemia. The covalent BTKis ibrutinib, acalabrutinib, and zanubrutinib...