Blood
Articles in this Issue
Outcomes of septic shock in immune thrombocytopenia
Abstract Background: Immune thrombocytopenia (ITP) is a chronic autoimmune disorder marked by immune-mediated platelet destruction and dysre...
Efficacy and safety of osivelotor in participants with sickle cell disease in a 12-week phase 2, multicenter, open-label, dose-finding trial and extension study
Abstract Background: Osivelotor is a sickle hemoglobin (HbS) polymerization inhibitor being investigated as a potential treatment for sickle...
Single-cell tracing of myeloid leukemia evolution in down syndrome reveals a latent progenitor bridging disease onset, progression and relapse
Abstract Children with Down syndrome (DS), or trisomy 21 (T21), have a markedly elevated risk of acute myeloid leukemia (ML-DS) in early chi...
Title: Association of CAR-T product type with incidence of cancer Therapy–Related cardiac dysfunction (CTRCD)
Abstract Background: Chimeric antigen receptor T-cell (CAR-T) therapy has transformed the treatment landscape for hematologic malignancies,...
Post-transplant cyclophosphamide facilitates preservation of intestinal innate lymphoid cells and intestinal stem cells.
Abstract Background Type 3 innate lymphoid cells (ILC3s) produce Interleukin-22 (IL-22) and contribute to epithelial maintenance and regener...
Chronic graft-versus-host disease after haploidentical transplantation in aplastic anemia: Clinical characteristics, risk factors, and survival outcomes
Abstract Background Aplastic anemia (AA) represents a critical hematological disorder, with allogeneic hematopoietic stem cell transplantati...
Outcome of children and adolescents with newly diagnosed T-cell acute lymphoblastic leukemia: Results of DFCI ALL consortium protocol 16-001
Abstract Background With intensified, multiagent chemotherapy protocols, outcomes for childhood T-cell acute lymphoblastic leukemia (T-ALL)...
Changing dogma regarding mutation primacy in acute myelogenous leukemia : Protein expression supersedes mutation status
Abstract INTRODUCTION: Current dogma is that Acute Myelogenous Leukemia (AML) arises from combinations of cytogenetic events and mutations in...
miRNA-mRNA analysis of mesenchymal stem cell derived extracellular vesicle mediated ex vivo expansion of hematopoietic stem cells
Abstract Background Ex vivo expansion of hematopoietic stem cells (HSCs) remains an unmet need in hematopoietic stem cell transplantation (H...
Outcomes in the 2nd decade following follicular lymphoma (FL) diagnosis: Long-term follow-up from the university of Iowa/Mayo Clinic SPORE molecular epidemiology resource (MER)
Abstract Introduction: Outcomes for FL have markedly improved, and the 10-year (yr) overall survival (OS) for patients (pts) diagnosed in th...
Embolic stroke of undetermined source with low ADAMTS13 level without evidence of microangiopathic hemolytic anemia- case series from single center experience
Abstract Background Low ADAMTS13 activity has been associated with ischemic stroke in a large cohort study (Michelle S,...
Efficacy and safety of linperlisib combined with azacitidine in patients with lymphoma
Abstract Objective: To retrospectively analyze the clinical efficacy and safety of linperlisib combined with azacitidine in patients with ly...
Integrated cell-free DNA and RNA sequencing recapitulates bone marrow genomic and transcriptomic alterations in multiple myeloma
Abstract Background: Molecular profiling of multiple myeloma (MM) is typically performed on CD138⁺ plasma cells enriched from bone marrow as...
Long progression-free survival with venetoclax consolidation in patients with high-risk chronic lymphocytic leukemia treated with ibrutinib.
Abstract Combined targeted therapy with BTK inhibitors and venetoclax (VEN) is an effective, time-limited treatment for patients (pts) with...
Associations between serum asparaginase activity and asparaginase-associated toxicities in pediatric ALL patients receiving calaspargase: A report from the DFCI ALL consortium
Abstract Background: L-asparaginase (ASP) is a universal component of acute lymphoblastic leukemia (ALL) therapy. Althou...
Rapidly progressive acute chest syndrome is associated with complement-mediated cell injury in adults with sickle cell disease
Abstract Introduction Rapidly progressive acute chest syndrome (RP-ACS) is a distinct phenotype of acute chest syndrome, characterized by ra...
Frontline nilotinib vs dasatinib in newly diagnosed chronic phase chronic myeloid leukemia: A propensity score analysis based on AIFA monitoring registries
Abstract Introduction Frontline second generation tyrosine kinase inhibitors increased the rate of deep molecular responses (DMR) but were al...
Maternal and fetal outcomes in immune-mediated thrombotic thrombocytopenic purpura: A scoping review
Abstract Introduction: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a life-threatening thrombotic microangiopathy due to a...
Mitochondrial suppression in Acute Myeloid Leukemia and Myelodysplastic Syndromes: A two-cohort transcriptomic analysis using GEO
Abstract Mitochondrial Suppression in Acute Myeloid Leukemia and Myelodysplastic Syndrome: A Two Cohort Transcriptomic Analysis Using GEO Da...
National trends and demographic disparities in Hodgkin disease mortality across the United States, 1999–2024
Abstract Background: Despite advances in treatment leading to significant improvements in outcomes for Hodgkin disease (...
Allogeneic hematopoietic stem cell transplantation in treatment of Shwachman- diamond syndrome: A Report of 25 Pediatric cases from a Single center
Abstract Objective: To explore the effectiveness of allogeneic hematopoietic stem cell transplantation(allo-HSCT) for Shwachman-Diamond Synd...
Mean corpuscular hemoglobin modulates HbF distribution and sub-phenotypes of sickle cell disease
Abstract Background Fetal hemoglobin (HbF) prevents sickle hemoglobin (HbS) polymerization that injures RBCs leading to...
Elevated NQO1 expression mediates proteasome inhibitor resistance and predicts adverse outcomes in multiple myeloma
Abstract Introduction: Proteasome inhibition (PI) remains a cornerstone of multiple myeloma (MM) therapy. Despite decades of clinical use, t...
Increased risk of gastrointestinal complications in older adults with multiple myeloma: A propensity matched nationwide cohort study
Abstract Background: Multiple myeloma (MM) is a plasma cell malignancy predominantly affecting older adults. Although th...
Safety and feasibility of high dose methotrexate addition to R-CHOP chemotherapy for prophylaxis and treatment of secondary cns involvement by large B-cell lymphoma in a community-based hospital setting
Abstract Introduction: High dose methotrexate (HDMTX) is commonly used in large B-cell lymphoma (LBCL) patients with CNS involvement (SCNSL)...