Blood
Articles in this Issue
Blastoid variant of double-hit lymphoma masquerading as acute lymphoblastic leukemia
Oral pathogens exacerbate chronic GVHD
Blastic plasmacytoid dendritic cell neoplasm in the absence of cutaneous involvement
Inflammation-driven NF-κB signaling represses ferroportin transcription in macrophages via HDAC1 and HDAC3
Abstract Anemia of inflammation is a prevalent comorbidity in patients with chronic inflammatory disorders. Inflammation causes hypoferremia and iron-restricted erythropoiesis by lim...
A belt-and-suspenders approach to PNH
New free light chain range decreases LC-MGUS
BRAFV600E induces key features of LCH in iPSCs with cell type–specific phenotypes and drug responses
Abstract Langerhans cell histiocytosis (LCH) is a clonal hematopoietic disorder defined by tumorous lesions containing CD1a+/CD207+ cells. Two severe complications of LCH are systemi...
How I treat quantitative fibrinogen disorders
Abstract Quantitative fibrinogen disorders, including afibrinogenemia and hypofibrinogenemia, are defined by the complete absence or reduction of fibrinogen, respectively. The diagno...
Serum free light chains in a racially diverse population including African Americans and populations from South Africa
Abstract Detection of light chain (LC) monoclonal gammopathies (MGs) traditionally relies on serum free LC (FLC) κ, λ, and their ratio (κ/λ) reference ranges based on a mostly White...
Oral inflammation and microbiome dysbiosis exacerbate chronic graft-versus-host disease
Abstract The oral microbiota, second in abundance to the gut, is implicated in chronic systemic diseases, but its specific role in graft-versus-host disease (GVHD) pathogenesis has b...
Long-term efficacy and safety of danicopan as add-on therapy to ravulizumab or eculizumab in PNH with significant EVH
Abstract Complement C5 inhibitor treatment with ravulizumab or eculizumab for paroxysmal nocturnal hemoglobinuria (PNH) improves outcomes and survival. Some patients remain anemic du...
Antibiotics: bad bugs for CAR-T cells?
Antibiotic-induced loss of gut microbiome metabolic output correlates with clinical responses to CAR T-cell therapy
Abstract Antibiotic (ABX)–induced microbiome dysbiosis is widespread in oncology, adversely affecting outcomes and side effects of various cancer treatments, including immune checkpo...
FDA-approved therapies for chronic GVHD
Abstact Despite novel prophylactic regimens, chronic graft-versus-host disease (cGVHD) remains a challenging complication after allogeneic hematopoietic cell transplantation. cGVHD c...