Blood
Articles in this Issue
Phase I/Ⅱ study evaluating the safety and preliminary efficacy of amulirafusp alfa (IMM0306) in combination with lenalidomide in patients with relapsed/refractory CD20-positive follicular lymphoma
Abstract Background: Follicular lymphoma (FL) is characterized by a relapsing and incurable course, wherein patients require multiple lines...
Hetrombopag for the treatment of chemotherapy-induced thrombocytopenia in advanced solid tumors: A multicenter, randomized, double-blind, placebo-controlled phase III trial
Abstract Introduction: Chemotherapy-induced thrombocytopenia (CIT) is a common complication resulting from the myelosuppressive effects of c...
Inhibition of the aryl hydrocarbon receptor eliminates leukemia stem cells in murine models of Acute Myeloid Leukemia
Abstract Leukaemia stem cells (LSCs) not only drive and sustain acute myeloid leukemia (AML), but also frequently survive chemotherapy and c...
Donor age matters: Selecting 10/10 muds under 35 enhances survival after ptcy allo-HCT
Abstract INTRODUCTION Allogeneic hematopoietic cell transplantation (allo-HCT) from a 10/10 HLA-matched unrelated donor...
Comparison of haploidentical donors for pediatric patients undergoing hematopoietic stem cell transplantation: 10-year outcomes from a single-center experience
Abstract Introduction: Donor age is one of the main prognostic factors in haploidentical transplantation, particularly in relation to the in...
Balancing the treatment outcomes: Survival and quality of life among older adults with AML
Abstract Background: The treatment of older adults with acute myeloid leukemia( AML) is rapidly changing. Survival in this population has hi...
Long-term follow-up of a prospective phase 2 Study of daratumumab plus bortezomib and dexamethasone in newly diagnosed mayo 2004 stage IIIA and IIIb light-chain amyloidosis
Abstract Introduction Mayo 2004 stage IIIB primary light chain amyloidosis (AL) patients exhibit poor outcomes and were excluded from most cl...
Longitudinal analysis of T-cell phenotype and function during bispecific antibody therapy
Abstract Introduction Bispecific antibodies (BsAbs) linking CD3 on T cells to CD20 on lymphoma cells (CD3xCD20) or to BC...
Distinct patterns of mutant ASXL1 over time and their implications for treatment failure (TF) and BCR::ABL1 mutation development in newly diagnosed patients with chronic myeloid leukemia in chronic phase (CML-CP) treated with asciminib (ASC) vs investigator-selected tyrosine kinase inhibitors (IS-TKI) in the ASC4FIRST study
Abstract Introduction: ASC, an allosteric BCR::ABL1 inhibitor, was recently approved in several countries for use in newly diagnosed patient...
Mis-splicing of Mdm4 activates TRP53 and impairs HSPC growth in a mouse model of myelodysplastic syndromes
Abstract Mutations in splicing factor genes (e.g. human U2AF1, SRSF2, SF3B1 and mouse U2af1, Srsf2, Sf3b1) occur in up to 50% of patients wi...
Transcriptional stratification reveals distinct molecular subtypes with treatment-specific outcomes in multiple myeloma patients from the GEM2017FIT trial
Abstract INTRODUCTION Multiple myeloma (MM) is a genetically and clinically heterogeneous plasma cell malignancy that remains incurable desp...
A partial neutralizing antibody to Protein C: Hemophilic bleeding preventive effects and thrombotic risks in nonhuman primates
Abstract The Protein C (PC) system maintains proper control of fibrin formation in hemostasis by downregulating the coagulation propagation...
Inhibition of DRP1–FIS1–Mediated mitochondrial fission as a novel strategy to prevent gvhd
Abstract Graft-versus-host disease (GVHD) remains a leading cause of non-relapse mortality following hematopoietic stem cell transplantation...
Evaluating patient preferences for chronic lymphocytic leukemia (CLL) in Korea: A discrete choice experiment
Abstract Introduction: CLL disease control and survival outcomes have improved since the introduction of Bruton tyrosine kinase inhibitors (...
Which molecular patterns of high-risk myeloid malignancies are concordantly identified using two machine learning algorithms?
Abstract Background: Higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) and secondary acute myeloid leukemia (sAML) share overlapping m...
Risk of relapse and mortality after non-myeloablative allogeneic stem cell transplant for Acute Myeloid Leukemia and myelodysplastic syndrome after fludarabine, cyclophosphamide, and 200 centigray total body irradiation with gvhd prophylaxis using post-transplant cyclophosphamide, sirolimus, and mycophenolate mofetil: Impact of maintenance chemotherapy
Abstract Introduction: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) can be curative for patients with high-risk myeloid ma...
Epigenetic targeting of SETD8 in multiple myeloma
Abstract Background: Multiple myeloma (MM) is a plasma cell malignancy and the second most common hematologic cancer. Despite effective front...
Post partum haemorrhage (PPH): Differences in coagulation patterns between vaginal deliveries and c-section - and why prophylactic txa is unlikely to be of advantage
Abstract Introduction: We earlier showed prepartum F XIII to be the main coagulation component to influence postpartum blood loss (PPBL) ove...
Real-world effectiveness and safety of belumosudil in pediatric chronic graft-versus-host disease: A retrospective cohort study
Abstract Background: Chronic graft-versus-host disease (cGVHD) remains a leading cause of non-relapse mortality and morbidity in pediatric p...
Refined genetic risk model with complex karyotype predicts outcomes of newly diagnosed acute myeloid leukemia treated with decitabine plus venetoclax
Abstract Introduction: The European LeukemiaNet (ELN) developed a new genetic risk score (ELN2024) for patients (pts) with newly diagnosed (...
Dynamic changes in the bone marrow niche following CD19-targeted CAR-T cell infusion in diffuse large B cell lymphoma (DLBCL).
Abstract Introduction CAR T cells have changed the treatment landscape of relapse/refractory (RR) DLBCL, offering a curative option. About h...
Mid-treatment CSF ctdna and MYD88 clearance outperform PET-CT in predicting response and survival to orelabrutinib-based induction in newly diagnosed PCNSL: A prospective biomarker study
Abstract Background Primary central nervous system lymphoma (PCNSL) is an aggressive extranodal non-Hodgkin lymphoma with limited tools for...
Incidence of asymptomatic deep vein thrombosis in patients with tunneled dialysis catheters undergoing routine venous mapping.
Abstract Background: Tunneled dialysis catheters (TDCs) are widely used for hemodialysis access but are associated with...
Plasma protein biomarkers associated with venous thromboembolism (VTE) and mortality in patients with cancer: A substudy of the avert trial
Abstract Background: Cancer is associated with a substantially elevated risk of venous thromboembolism (VTE), but this risk varies considerab...
Outcomes of inpatient and outpatient chimeric antigen receptor T-cell therapy (CAR T) in newly authorized treatment centers (ATCs) in the United States (US)
Abstract Introduction: CAR T has transformed the treatment landscape for hematologic malignancies. Despite its clinical success, access to C...