Blood
Articles in this Issue
Pre-clinical characterization and process development of a BCMA-directed CAR NK-cell therapy product for relapsed/refractory multiple myeloma
Abstract The burgeoning field of cellular therapy, in particular chimeric antigen receptor (CAR) T-cell therapy, has revolutionized the trea...
Cost and quality of life analysis associated with allogeneic hematopoietic progenitor transplantation
Abstract Introduction Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a complex procedure that involves significant clinica...
Platelet decrease and efficacy of platelet-rich plasma return for CAR-T lymphocyte apheresis in low-weight patients
Abstract Chimeric Antigen Receptor (CAR) T-cell therapy has emerged as a transformative treatment for relapsed or refractory acute lymphobla...
Implicating a functional domain (SPOC) of RBM15 in the pathogenesis of RBM15::MKL1 fusion protein-induced acute megakaryoblastic leukemia
Abstract In acute megakaryoblastic leukemia (AMKL), immature megakaryoblasts accumulate due to excessive proliferation and failure to termin...
Role of DNA damage sensing and TP53 function as modulators of sensitivity to calicheamicin-based antibody-drug conjugates (ADCs) for acute leukemia
Abstract Background: ADCs have long been pursued to improve outcomes in acute leukemia, with focus on CD33 (for acute myeloid leukemia [AML]...
Superior long-term outcomes with fludarabine and melphalan reduced intensity regimen in older AML/MDS patients undergoing allogeneic stem cell transplantation: An analysis of CIBMTR data
Abstract Introduction: Reduced intensity and non-myeloablative (RIC/NMA) conditioning regimens are routinely utilized in allogeneic hematopo...
Myeloproliferative neoplasms in Mexico: An analysis of clinical features, driver mutations, and disease progression patterns in a case series.
Abstract Myeloproliferative neoplasms (MPNs) are chronic hematologic malignancies characterized by clonal myeloid proliferation, risking pro...
Real-world clinical outcomes with novel agent combination therapies for the frontline treatment of pediatric and adult advanced-stage Hodgkin lymphoma
Abstract Introduction: Brentuximab vedotin (BV) and nivolumab (N) have resulted in significant progress in the treatment of advanced-stage H...
HEM-ismart: An international proof-of-concept therapeutic stratification trial of molecular anomalies in relapsed or refractory hematological malignancies in children
Abstract Background and Significance The prognosis of pediatric patients with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL) o...
Elevation of liver health biomarkers before and after etranacogene dezaparvovec gene therapy in hemophilia B: Associations with long-term clinical outcomes
Abstract Introduction Gene therapy with etranacogene dezaparvovec has emerged as a transformative treatment for individuals with hemophilia...
Acquired regions of homozygosity in adult B-cell acute lymphoblastic leukemia: Insights from a machine learning–powered analysis of genomic data from a multicenter cohort
Abstract INTRODUCTION Acquired regions of homozygosity (aROHs), due to mitotic recombination between homologous chromoso...
In multiple myeloma patients, autologous stem cell transplants abrogate the difference of treating them with two or three drug combinations: Real world data from a single institution in a middle-income country.
Abstract Background: Currently, the standard treatment of MM is a three-drug regimen that includes immunomodulators, corticosteroids, and pr...
Orelabrutinib combined with R-CDOP regimen for first-line treatment of diffuse large B-cell lymphoma with high-risk CNS-IPI
Abstract Introduction Diffuse large B-cell lymphoma (DLBCL) relapse in the central nervous system (CNS) is a highly destructive complication...
Targeting β-catenin nuclear export and protein degradation in high-risk acute lymphoblastic leukemia
Abstract Background and Significance: A recurrent, gain-of-function mutation in the nuclear export molecule XPO1 (E571K) has been identified...
Zanubrutinib combined with bendamustine and rituximab in previously untreated patients with advanced follicular lymphoma: A prospective, open-label, single-arm phase II clinical study
Abstract Background Follicular lymphoma (FL) is the most common indolent non-Hodgkin lymphoma (NHL), accounting for approximately 20-30% of...
First 20-patient safety and efficacy data from nexicart-2, the first u.S. trial of CAR-T in R/R light chain (AL) amyloidosis, nxc-201
Abstract Background: No FDA approved treatments exist for relapsed/refractory (RR) AL Amyloidosis. Chimeric antigen receptor T-cell (CAR-T)...
Clone-specific epigenetic regulatory mechanisms in ASXL1-mutant chronic myelomonocytic leukemia
Abstract Introduction: ASXL1-mutant (mt) Chronic Myelomonocytic Leukemia (CMML) is an aggressive myeloid neoplasm characterized by increased...
Black lives advocating for clot knowledge (B.L.A.C.K) national blood clot alliance church bus tour: A community-based blood clot education and awareness campaign
Abstract Background: Black Americans are disproportionally affected by venous thromboembolism (VTE) and experience higher incidence, greater...
Treatment related outcomes of very old (>85 years) diffuse large b-cell lymphoma patients.
Abstract Background: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, with a significant proportion...
Promising safety and efficacy of equecabtagene autoleucel (eque-cel) followed ASCT in ultra high-risk multiple Myeloma (UHR-MM) patients: primary real world data from a single center
Abstract Background:Although the overall survival of multiple myeloma (MM) has improved significantly, patients with ultra-high-risk feature...
Real world outcomes comparing the use of GLP-1 receptor agonists in patients with CML and comorbid obesity: A propensity score matched analysis from global federated health research network
Abstract Introduction Glucagon-like peptide-1 (GLP-1) receptor agonists are widely used for the treatment of type 2 diabetes and obesity. Em...
NLRP6 regulates ZAP-70-erk signaling in both murine and human T cells and influences acute graft-versus-host disease(GVHD)
Abstract The Nlrp6 (NOD-like receptor family pyrin domain-containing 6) inflammasome is essential for innate immune responses and maintainin...
A fellow-led communication skills training (CST) curriculum for hematology/oncology (HO) trainees
Abstract Background: High-quality, equitable HO care depends on clinicians' ability to effectively communicate complex,...
An orally bioavailable and dual-targeting GSPT1 and CK1α molecular glue degrader targets double-hit lymphoma cells
Abstract Therapeutic options for aggressive and high-risk lymphomas, such as double-hit lymphoma (DHL), remain limited. As a novel therapeut...
Double-blind randomized study to evaluate the effect of hydroxycarbamide on albuminuria in adults with sickle cell disease: Sikamic (SIklos on Kidney Function and AlbuMInuria Clinical Trial)
Abstract Background The optimal therapeutic strategies for adult sickle cell disease (SCD) patients with nephropathy remains to be determine...