Blood
Articles in this Issue
The fellowship of the ring: TMEM187 guides iron to heme
Blinatumomab consolidation for high-risk Ph− B-cell acute lymphoblastic leukemia: the GRAALL-2014/B-QUEST study
Abstract Intensified chemotherapy regimens have improved outcomes in adults with Philadelphia chromosome–negative (Ph−) B-cell acute lymphoblastic leukemia (B-ALL), yet relapse rem...
Oxidized PDI promotes thrombus formation in oxidative stress
Abstract Protein disulfide isomerase (PDI) functions in thrombus formation in vivo and represents a viable target for antithrombotic therapy. PDI is a redox sensor that can either...
A QUEST to improve outcomes for adults with high-risk B-ALL
TMEM187 is a novel brakelike modulator in the regulation of erythropoiesis
Abstract Erythropoiesis, the process of red blood cell production, is highly dependent on iron uptake by transferrin and its receptor, transferrin receptor 1 (TfR1). However, the m...
Bollard CM, Heslop HE. A reassessment of anti–CAR T-cell expansion strategies. <i>Blood</i> . 2026;147(22):2561-2562.
Crossing the trial-practice chasm in CAR-T for relapsed LBCL
Consensus recommendations for malignant histiocytic neoplasms (histiocytic, Langerhans, and interdigitating dendritic cell sarcomas)
Abstract Malignant histiocytic neoplasms (MHNs) are rare tumors derived from the mononuclear phagocyte system (MPS), encompassing histiocytic sarcoma, Langerhans cell sarcoma, inte...
Deregulation of <i>FOXF1</i> / <i>FENDRR</i> from t(14;16)(q32;q24) defines a subtype of high-risk lineage ambiguous leukemia
Abstract Despite great progress in understanding the genomic basis of immature T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma (T-ALL) and acute leukemias of ambiguous l...
<i>BCL11B</i> enhancer hijacking by t(14;16)(q32;q24) translocation defines a novel high-risk subtype of T-ALL
Abstract The molecular classification of T-cell acute lymphoblastic leukemia (T-ALL) remains incomplete, limiting risk stratification and the development of targeted therapies. Enh...
Maternal anti-HPA-1a antibodies block αIIbβ3/αvβ3 integrin activation, and blockade correlates with FNAIT disease severity
Abstract Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a disorder caused by a mismatch in human platelet antigens (HPAs), leading to maternal antibody formation and platele...
Does epitope specificity dictate FNAIT severity?
Real-world outcomes for lisocabtagene maraleucel in patients with relapsed or refractory large B-cell lymphoma
Abstract This study assessed real-world effectiveness and safety of lisocabtagene maraleucel (liso-cel) in patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL), inc...