Blood
Articles in this Issue
A randomized phase 2 study of ipilimumab, nivolumab, and brentuximab vedotin in patients with relapsed Hodgkin lymphoma
Abstract The phase 1/2 Intergroup study E4412 investigated checkpoint blockade with nivolumab (Nivo) and ipilimumab (Ipi) combined with the CD30 targeting antibody-drug conjugate b...
<i>Plasmodium knowlesi</i> can adapt to infect Duffy-negative erythrocytes
Abstract Plasmodium knowlesi, a zoonotic malaria species, has become a significant public health concern in Southeast Asia. In regions such as Malaysia and southern Thailand, P kno...
DC-SIGN binding to the surface immunoglobulin oligomannose-type glycans promotes follicular lymphoma cell adhesion and survival
Abstract The occupation of the surface immunoglobulin antigen-binding site by oligomannose-type glycans (sIg-Mann) is a tumor-specific posttranslational modification of classic fol...
The transposable element–PARP axis underpins synthetic lethality and immunogenic vulnerability in blood cancer
Abstract Transposable elements (TEs) are emerging regulators of hematopoiesis and leukemia, creating vulnerabilities exploitable for therapy. Recent evidence shows that TE reactiva...
Nuclear architecture: a mechanical lever for HSC fitness
Plasmin modulates neutrophilic inflammation and alveolar macrophage function, protecting mice from pneumococcal pneumonia
Abstract Accumulating evidence supports the proresolving actions of the plasminogen/plasmin (Plg/Pla) system during inflammation, beyond its classical role in fibrin degradation. H...
Immune clues to infection risk in myeloma
Silencing of PAI-1 using siRNA-lipid nanoparticles reduces thrombosis and prolongs life span in murine models
Abstract Plasminogen activator inhibitor 1 (PAI-1) is an inhibitor of fibrinolysis, thereby promoting blood clot stabilization. PAI-1 contributes to thrombosis, diet-induced obesit...
SIGN of the times: DC-SIGN and the follicular lymphoma niche
Checkpoint blockade in HL: is transplant still needed?
A siRNA slice of PAI
Nucleoplasmic ZNF467 condensates boost hematopoietic stem cell engraftment via ICAM1-mediated mechanical reprogramming
Abstract Hematopoietic stem cell (HSC) transplantation is a life-saving therapy for immune deficiencies and hematologic malignancies, but its efficacy is limited by poor engraftmen...
Plasmin tames lung inflammation by redirecting immune cells
<i>Plasmodium</i> gets inside through the back door
Targeting donor XCR1+ and CD11b+ dendritic cells prevents Th1- and Th17-dependent GVHD within the gastrointestinal tract
Abstract Acute graft-versus-host disease (GVHD) of the gastrointestinal tract is a primary cause of early transplant mortality after bone marrow transplantation (BMT), driven by lo...
Knox AVC, Cominsky LY, Sun D, et al. One hundred thirty-four germ line PU.1 variants and the agammaglobulinemic patients carrying them. <i>Blood.</i> 2025;145(22):2549-2560.
Dendritic cells team up to drive gut GVHD
CDK8/CDK19 inhibition restores T-cell homeostasis in primary immune thrombocytopenia
Abstract CD4+CD25+Foxp3+ regulatory T cells (Tregs) are pivotal negative regulators of the adaptive immune system. Abnormalities in the number and/or function of Tregs contribute t...
Dissecting the genetic threads underlying the fabric of pediatric myelofibrosis
Strati P, Ahmed S, Furqan F, et al. Prognostic impact of corticosteroids on efficacy of chimeric antigen receptor T-cell therapy in large B-cell lymphoma. <i>Blood</i> . 2021;137(23):3272-3276.
Toggling STAT to restore T-cell homeostasis in ITP
Immune biomarkers of increased infection risk in multiple myeloma
Abstract Infection remains a leading cause of morbidity in multiple myeloma. Preventing infections is paramount and immune profiling could reflect the cumulative effect of host-, t...