Blood
Articles in this Issue
Deciphering the neurohistiocytosis spectrum
The ASH HematOmics Program supports integrative analysis of genomic and clinical data in hematologic diseases
Abstract The increasing availability of genomic and transcriptomic sequencing has uncovered diverse genomic alterations and distinct gene expression profiles driving hematologic di...
A case of vitreoretinal PTLD after HSCT for aplastic anemia
Modulation of the E3-ubiquitin ligase RNF217 alters ferroportin levels in enterocytes and iron loading in murine hemochromatosis
Abstract Excess iron induces tissue toxicity in various conditions, including hereditary hemochromatosis (HH). Hepcidin, a liver-derived hormone encoded by the HAMP gene, plays a p...
Platelet Drp1 phosphorylation provides a platform for immune-based platelet function testing
Abstract Dynamin-related protein 1 (Drp1) is an abundant platelet protein best known for its function in mitochondrial fission. However, little is known about how Drp1 is controlle...
How I treat plasma cell leukemia
Abstract Plasma cell leukemia (PCL) represents an exceptionally aggressive plasma cell malignancy defined by ≥5% circulating plasma cells in the peripheral blood of patients otherw...
Phospho-Drp1: rewiring platelet function testing
Extended HLA haplotypes and transplant survival
Abstract The benefit of extended phased (∼) HLA class I∼class III∼class II haplotypes in reducing the mortality after hematopoietic cell transplantation is unknown and requires inf...
Digesting FPN1 (SLC40A1) in intestinal iron absorption
CHORUS line: a leg up for HHT
Take yourself on ASHOPing spree
Clinical spectrum of hereditary hemorrhagic telangiectasia: data from the Comprehensive HHT Outcomes Registry of the US (CHORUS)
Abstract Hereditary hemorrhagic telangiectasia (HHT), an autosomal dominant vasculopathy affecting 1 in 5000 individuals, is the second most common inherited bleeding disorder worl...
Polycomb repressive complex 2 insufficiency underlies myeloid leukemia in Down syndrome
Abstract Children with Down syndrome (DS) have an elevated risk of developing myeloid leukemia (ML; ML in DS [ML-DS]). In addition to mutations in GATA1, which generate the truncat...
Breaking PRC2: when cohesion tips the balance in ML-DS
Vekariya U, Toma M, Nieborowska-Skorska M, et al. DNA polymerase θ protects leukemia cells from metabolically induced DNA damage. <i>Blood</i> . 2023;141(19):2372-2389.
HLA class III unmasked: a new dimension of haplo risk
Pathogenic myeloid phenotypes drive disease pathology in a novel human neurohistiocytosis model
Abstract Innate immunity is increasingly recognized as a driver of neurodegeneration, although pathogenic mechanisms are incompletely understood. Langerhans cell histiocytosis (LCH...
Molecular mechanism of cleavage at R271 during prothrombin activation revealed by cryo-EM
Abstract The conversion of the inactive zymogen prothrombin to the active protease thrombin in the common pathway of the coagulation cascade is the molecular event responsible for...