Blood
Articles in this Issue
Rbm38 binds <i>Fech</i> pre-mRNA to prevent anemia and porphyria
Genomic landscape of IgM-MGUS and patients with stable or progressive asymptomatic Waldenström macroglobulinemia
Abstract Immunoglobulin M (IgM) monoclonal gammopathy of undetermined significance (IgM-MGUS) and asymptomatic Waldenström macroglobulinemia (WM; aWM) are precursor conditions of s...
Exhaustion is getting complicated
Outnumbered: T-cell dominance breaks BCMA-TCE resistance
Molecular modeling of Waldenström macroglobulinemia
Prognostic value of premaintenance FDG PET/CT response in patients with newly diagnosed myeloma from the CASSIOPEIA trial
Abstract The CASSIOPEIA trial demonstrated superior progression-free survival (PFS) with the addition of daratumumab to bortezomib, thalidomide, and dexamethasone (D-VTd) induction...
An immunostimulatory CELMoD combination overcomes resistance to T-cell engagers caused by a high multiple myeloma burden
Abstract Bispecific T-cell engagers (TCEs) targeting B-cell maturation antigen (BCMA) and CD3, induce deep hematologic responses in ∼60% of heavily pretreated patients with multipl...
<i>LEF1</i> intragenic deletions: is Wnt’er coming for T-ALL?
MECOM is a master repressor of myeloid differentiation through dose control of <i>CEBPA</i> in acute myeloid leukemia
Abstract The transcription factor MECOM, located at 3q26, is essential for hematopoietic stem cells in healthy individuals. Enhancer translocations, due to 3q26 rearrangements, dri...
Human herpesvirus 6 viremia and encephalitis in CAR T-cell recipients
Abstract Human herpesvirus 6 reactivation in chimeric antigen receptor T-cell recipients is reported to be rare. Our patient cohort (n = 119) experienced a sevenfold higher inciden...
Breaking the silence: restoring <i>CEBPA</i> to fight leukemia
More than an emotional support PET
Rbm38 deficiency impairs erythroid heme biosynthesis and induces porphyria via reduced ferrochelatase expression
Abstract RNA splicing and processing are critical for erythropoiesis, because dysregulation of RNA splicing ultimately disrupts protein synthesis. The RNA-binding protein Rbm38 is...
<i>LEF1</i> intragenic deletion induces a dominant-negative isoform and unveils a Wnt/β-catenin vulnerability in T-ALL
Abstract T-cell acute lymphoblastic leukemia (T-ALL) represents a group of aggressive hematological malignancies characterized by unfavorable prognosis, urging the need for innovat...
Chronic NK cell activation results in a dysfunctional, tissue resident–like state mediated by KLF2 deficiency
Abstract Adoptive transfer of natural killer (NK) cells can induce complete remissions in 30% to 50% of patients with refractory acute myeloid leukemia and lymphoma. Although blood...
CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias
Abstract Acute myeloid leukemias (AMLs) have an overall poor prognosis with many high-risk cases co-opting stem cell gene regulatory programs, but the mechanisms through which thes...