Blood
Articles in this Issue
Circular RNA in chronic myeloid leukemia
PU.1-activated genomic regions define low-risk MDS subsets characterized by immune dysregulation and disease progression
Abstract Myelodysplastic syndromes (MDS) are heterogeneous myeloid neoplasms associated with an increased risk of progression to secondary acute myeloid leukemia (sAML). This study...
Pruning the Waldenström macroglobulinemia evolutionary tree
Next-generation IHC: identifying <i>TP53</i> mutation origin in a bone marrow with concurrent CLL and AML
Proteasome subunit PSMD1 is a key therapeutic target in multiple myeloma
Abstract We found that PSMD1, a key subunit of the 19S proteasome regulatory particle, was overexpressed and correlated with poor prognosis in multiple myeloma (MM). Genetic deplet...
Nuclear transcriptional condensates as drivers and therapeutic targets in <i>NPM1</i> -mutated AML
Abstract NPM 1-mutated acute myeloid leukemia (AML) is driven by aberrant HOX/MEIS1 expression, whose mechanistic basis remained unresolved for years. Recent paradigm-shifting stud...
DHODH as a targetable metabolic Achilles’ heel for chemotherapy-resistant B-ALL
Abstract Relapse remains a major barrier to survival in B-cell acute lymphoblastic leukemia (B-ALL). Both activation of B-cell signaling pathways and increased glucose consumption...
The role of activated platelets in cerebral malaria pathogenesis
CHIP and inflammatory bowel disease: adding fuel to the fire
Anti-CD4 antibody–modulated transplants for GVHD prevention in hematopoietic cell transplantation
Abstract Graft-versus-host disease (GVHD) remains one of the major complications following allogeneic hematopoietic cell transplantation. Currently, immunosuppressants are used for...
<i>circPCMTD1</i> : a protein-coding circular RNA that regulates DNA damage response in <i>BCR/ABL</i> <i>1</i> -positive leukemias
Abstract Circular RNAs (circRNAs) are a novel class of RNA transcripts that regulate important cellular functions in health and disease. In this study, we report on the functional...
Inflammatory bowel disease–induced inflammation augments clonal hematopoiesis of indeterminate potential through Ref-1
Abstract Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by age-related somatic mutations in hematopoietic stem and progenitor cells (HSC/Ps) and is correla...
Evolution of tumor subclones and T-cell dynamics underlie variable ibrutinib responses in Waldenström macroglobulinemia
Abstract To elucidate the molecular basis underlying differential responses and resistance to ibrutinib in Waldenström macroglobulinemia (WM), we conducted a prospective phase 2 tr...
Heme-induced ITAM signaling exacerbates malaria-associated neuropathogenesis through activation of platelet mTOR
Abstract Malaria, caused by Plasmodium parasites, has a worldwide disease burden of over 250 million cases and ∼600 000 deaths annually. A leading cause of malaria-associated morta...