Blood
Articles in this Issue
Good flatmates: immature neutrophils protect bone integrity
Immune dysfunction after cancer remission: scar or disease?
Chauhan D, Li G, Hideshima T, et al. Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance. <i>Blood</i> . 2003;102(9):3379-3386.
Transposable elements as novel therapeutic targets for PARPi-induced synthetic lethality in PcG-mutated blood cancer
Abstract Loss-of-function (LoF) mutations frequently found in human cancers are generally intractable by classical small molecule inhibitor approaches. Among them are mutations affec...
Acalabrutinib-obinutuzumab improves survival vs chemoimmunotherapy in treatment-naive CLL in the 6-year follow-up of ELEVATE-TN
Abstract Acalabrutinib is a Bruton tyrosine kinase inhibitor approved for the treatment of chronic lymphocytic leukemia. We present results from ELEVATE-TN after a median follow-up o...
Inflammatory memory of stem cells: implications for hematologic diseases
Abstract Immunological memory in adaptive and innate immune cells is well characterized, enabling enhanced responses upon secondary challenges. However, it has only been recently app...
ClpP: a new Achilles' heel in myeloma
Not in the beginning
Chavez JC, Dickinson M, Munoz J, et al. Three-year follow-up analysis of first-line axicabtagene ciloleucel for high-risk large B-cell lymphoma: the ZUMA-12 study. <i>Blood</i>. 2025;145(20):2303-2311.
Large B-cell lymphoma imprints a dysfunctional immune phenotype that persists years after treatment
Abstract Immunotherapy has become standard of care in the treatment of diffuse large B-cell lymphoma (DLBCL). Changes in immunophenotypes observed at first diagnosis predict therapy...
Mac-Man clearance of alloreactive T cells in GVHD
Bone marrow neutrophil progenitors suppress osteoclast formation in murine cortical and trabecular bone
Abstract In inflammation, circulating neutrophils indirectly damage the skeleton by inducing formation of bone-resorbing osteoclasts. However, neutrophil progenitors in marrow have n...
The mitochondrial protease ClpP is a metabolic vulnerability and an immunogenic trigger against multiple myeloma
Abstract Orchestrating key homeostatic functions, mitochondria likely entail cancer vulnerabilities. Moreover, because of their bacterial ancestry, they can release potent immunogeni...
Plasminogen activation and plasmin activity are not necessary to prevent venous thrombosis/thromboembolism
Abstract Suppression of plasminogen activation and/or plasmin activity (PA) reduces blood loss and decreases hemorrhage-related death. However, whether the endogenous PA system is a...
TE-PARPi as a precision weapon against hematologic cancers
Augmented CD47 expression impairs alloreactive T-cell clearance after allo-HCT
Abstract Graft-versus-host disease (GVHD) ensues as the most common nonrelapse complication after allogeneic hematopoietic cell transplantation (allo-HCT). A pivotal goal in GVHD man...