Blood
Articles in this Issue
Ferric carboxymaltose increases fracture risk in patients and reduces bone formation in mice with iron deficiency anemia
Abstract Modern IV iron formulations allow treatment of iron deficiency anemia (IDA) with 1 or 2 infusions. Ferric carboxymaltose (FCM) is a widely used IV iron, which causes hypop...
Is low a go for pediatric AML?
EBV and immunodeficiency: the odd couple drawn to the brain
CD28+ CD8+ Tem cells with a STAT1-dependent glucocorticoid receptor deficit contribute to steroid-refractory acute GVHD
Abstract Steroid-refractory (SR) disease develops in a substantial fraction of patients with grade II to IV acute graft-versus-host disease (aGVHD) and is associated with poor long...
ELISA-negative HIT: antibody recognition and relevance
Bachmann PS, Piazza RG, Janes ME, et al. Epigenetic silencing of <i>BIM</i> in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition. <i>Blood</i> . 2010;116(16):3013-3022.
Updated consensus guidelines for the diagnosis and management of patients with HCL and HCL variant
Abstract Hairy cell leukemia (HCL) and HCL variant (HCLv) are distinct, rare, and chronic splenic B-cell lymphomas/leukemias that partially overlap in clinicopathologic presentatio...
Chari A, van de Donk NWCJ, Dholaria B, et al. Talquetamab plus daratumumab for the treatment of relapsed or refractory multiple myeloma in the TRIMM-2 study. <i>Blood</i> . 2025;146(24):2902-2913.
A step toward streamlining HIT diagnosis
A bone to pick with ferric carboxymaltose
Low- vs standard-dose regimens as induction for pediatric AML: a multicenter, randomized noninferiority trial
Abstract Intensive chemotherapy is standard for acute myeloid leukemia (AML) but carries high risks of life-threatening complications, particularly in vulnerable patients. We aimed...
Non-PF4/heparin-binding, platelet-activating antibodies in heparin-induced thrombocytopenia
Abstract The hallmark of heparin-induced thrombocytopenia (HIT) is the presence of immunoglobulin G (IgG) antibodies against platelet factor 4/heparin (PF4/H) complexes, typically...
Identifying steroid-refractory aGVHD before it happens
Engineering single-chain variable fragments to identify pathogenic antibodies in heparin-induced thrombocytopenia
Abstract Heparin-induced thrombocytopenia (HIT) is characterized by the production of pathogenic antibodies that bind to complexes of platelet factor 4 (PF4) and heparin, causing p...
Genomics reboot for secondary myelofibrosis
Genomic profiling for decision-making in post–polycythemia vera and post–essential thrombocythemia myelofibrosis
Abstract Secondary myelofibrosis (SMF) represents a late stage of polycythemia vera (PV) and essential thrombocythemia (ET), with overall survival (OS) currently defined by the mye...
Therapy-related AML with MECOM rearrangement, biallelic TP53 inactivation, and striking nuclear abnormalities
When the KAT’s away, vulnerability for AML comes out to play
Inhibition of p300/CREBBP catalytic activity drives context-dependent transcriptional activation in AML
Abstract The lysine acetyltransferase (KAT) activity of EP300 lysine acetyltransferase (p300)/CREB-binding protein (CREBBP) has traditionally been linked to transcriptional activat...
Immunodeficiency-associated primary CNS lymphomas: an International Primary CNS Lymphoma Collaborative Group study
Abstract Immunodeficiency-associated primary central nervous system lymphoma (ID-PCNSL) represents a clinicopathologically distinct PCNSL subtype, for which large studies and progn...