Blood
Articles in this Issue
Patient-derived lymphoma spheroids reveal predictive markers of glofitamab resistance in relapsed/refractory B-NHL
Abstract Bispecific antibodies (bsAbs) such as glofitamab represent a promising therapeutic approach for relapsed/refractory B-cell non-Hodgkin lymphoma (R/R B-NHL), but resistance...
Another “one stone hit two birds” candidate in chronic GVHD
Clonal tracing of blood stem cells across mouse and human lifespans
Abstract For over 60 years, blood researchers have been counting clones with every tool at their disposal. Inspired by phage and fly geneticists, Till and McCulloch irradiated mice...
CSF-1R inhibition and lenalidomide synergize to promote myeloma control after autologous stem cell transplantation
Abstract Autologous stem cell transplantation (ASCT) with maintenance lenalidomide remains the mainstay of consolidation therapy for eligible patients with multiple myeloma, but pr...
Methylation-based lineage tracing in cancer
Abstract The evolutionary history of cancers is encoded in molecular patterns that provide critical insights into the mechanisms of tumor progression. However, reconstructing cance...
Homeodomain-driven oncogenic diversion to a γδTCR phenotype in T-cell acute lymphoblastic leukemia
Abstract T-cell acute lymphoblastic leukemia (T-ALL) results from the malignant transformation of thymocytes blocked in their differentiation. Surface expression of the γδ T-cell r...
The evolution of hematopoietic models through a clonal lens
Abstract Hematopoiesis is a tightly regulated process through which a small pool of stem cells sustains the lifelong production of all blood cell types in response to physiological...
United forces bring down menin resistance in AML
Kumskova M, Flora GD, Nayak MK, et al. Platelet defects in patients and mice with Ehlers-Danlos syndrome. <i>Blood</i> . 2026;147(9):987-997.
The fibrinogen αC region promotes arterial thrombosis in the context of hypofibrinogenemia
Abstract Hypofibrinogenemia reduces experimental venous thrombosis, but the impact on arterial thrombosis remains unknown. In a cohort of patients with congenital fibrinogen disord...
Tipping the balance on lenalidomide maintenance
Introduction to a review series on clonal tracking in hematopoiesis
Over the past decade, advances in single-cell genomics, lineage tracing, and computational phylogenetics have transformed our understanding of hematopoiesis by enabling detailed reconstruction of hema...
Distinct effects of <i>CREBBP</i> missense and truncating mutations
Predicting and reversing T-cell engager resistance
Measurable residual disease in myeloma: a MyRiaD of findings
T-ALL: the origin story
BET inhibition blunts antibody production and macrophage-mediated fibrosis to restore lung function in murine cGVHD
Abstract Chronic graft-versus-host disease (cGVHD) significantly contributes to late mortality after allogeneic stem cell transplantation, with bronchiolitis obliterans syndrome (B...
Shrouded in a starry sky: a case of AML-MRC with <i>KMT2A</i> amplification mimicking Burkitt-like morphology
Overcoming menin inhibitor resistance in AML cells with combinations including BET proteins and a dual BRG1/BRM inhibitor
Abstract Menin inhibitors (MI) disrupt the binding of menin to mixed-lineage leukemia 1 (MLL1), leading to the repression of MLL1 or MLL1-fusion protein target genes, including red...
Differential role of <i>CREBBP</i> missense and truncating mutations in germinal center development and lymphomagenesis
Abstract Truncating and missense mutations of the CREBBP gene are highly prevalent in follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL), the most common lymphoid m...
Isatuximab, bortezomib, lenalidomide, and dexamethasone for multiple myeloma: dynamics of MRD negativity in the IMROZ study
Abstract Quadruplet therapy with Isa-VRd (isatuximab, Velcade [bortezomib], Revlimid [lenalidomide], and dexamethasone) followed by Isa-Rd in the randomized phase 3 IMROZ study pro...