Blood
Articles in this Issue
Preclinical efficacy of CDK7 inhibitor–based combinations against myeloproliferative neoplasms transformed to AML
Abstract Rising blast percentage or secondary acute myeloid leukemia (sAML) transformation in myeloproliferative neoplasms (MPNs) leads to JAK1/2 inhibitor (JAKi) therapy resistance...
The dark zone of CNS relapse in DLBCL
The hepcidin-ferroportin axis modulates liver endothelial cell BMP expression to influence iron homeostasis in mice
Abstract The liver hormone hepcidin regulates systemic iron homeostasis to provide enough iron for vital processes while limiting toxicity. Hepcidin acts by degrading its receptor fe...
BMPs and iron: the ins and outs
No exit: targeting RNA export in T-cell malignancy
CNS relapse in high-grade B-cell lymphoma with <i>MYC</i> and <i>BCL2</i> rearrangements and dark-zone signature–expressing DLBCL
Abstract High-grade B-cell lymphoma with MYC and BCL2 rearrangements (HGBCL-DH-BCL2), or “double-hit lymphoma,” has been associated with a high risk of central nervous system (CNS) r...
The GATA-3–dependent transcriptome and tumor microenvironment are regulated by eIF4E and XPO1 in T-cell lymphomas
Abstract The transcription factor GATA-binding protein 3 (GATA-3) and the transcriptional program it regulates have emerged as oncogenic drivers across diverse T-cell lymphomas (TCLs...
Menin inhibitors in the treatment of acute myeloid leukemia
Abstract Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by the (oligo)clonal expansion of myeloid progenitor cells. Despite advances in treatmen...
How I treat blastic plasmacytoid dendritic cell neoplasm
Abstract Historically, treatment options for blastic plasmacytoid dendritic cell neoplasm (BPDCN) were limited to conventional chemotherapy, adopted from regimens used to treat acute...
Antibodies to PF4 in severe COVID-19: same but different
Asciminib plus dasatinib and prednisone for Philadelphia chromosome–positive acute leukemia
Abstract Dasatinib is an effective treatment for Philadelphia chromosome–positive (Ph+) acute leukemia, but some patients develop resistance. Combination treatment with dasatinib and...
Acute myeloid leukemia with <i>BCL6</i> and <i>KMT2A</i> dual rearrangements
β-Thalassemia minor is associated with high rates of worsening anemia in pregnancy
Abstract We identified 347 pregnancies in patients with β-thalassemia minor. Hemoglobin was &lt;9 g/dL in 31% during third trimester and 7.6% at delivery. Postpartum hemorrhage o...
De-JAKing resistance with CDK7 inhibitors in post-MPN sAML
Asciminib for Ph+ ALL: a step forward?
Prothrombotic antibodies targeting the spike protein's receptor-binding domain in severe COVID-19
Abstract Thromboembolic complication is common in severe coronavirus disease 2019 (COVID-19), leading to an investigation into the presence of prothrombotic antibodies akin to those...