Blood
Articles in this Issue
Microclone with megaimpact
Biallelic loss-of-function mutations in <i>BPNT1</i> cause vitamin B12–dependent megaloblastic anemia
Abstract We identified biallelic loss-of-function BPNT1 mutations in 3 patients with recurrent vitamin B12–dependent megaloblastic anemia. Mechanistically, BPNT1 deficiency caused...
Single-cell MRD: from detection to direction
MLL3 and MLL4 sustain hematopoietic stem cell multipotency by opposing a B-cell default state
Abstract Hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) are sustained by networks of transcription factors and epigenetic regulators that prime lineage-specific...
Crumpled cytoplasm, clear diagnosis: the iconic morphology of Gaucher disease
Inhibition of high CXCR4 with motixafortide and absence of single-cell MRD predict outcome after AML consolidation
Abstract Relapse after remission remains the primary cause of treatment failure in acute myeloid leukemia (AML), underscoring the need for strategies to eliminate residual leukemic...
Prognostic impact of <i>FLT3</i> -ITD microclones in young adults with acute myeloid leukemia treated with intensive chemotherapy
Abstract FLT3 internal tandem duplications (FLT3-ITD) are major genetic events in acute myeloid leukemia (AML). Although the clinical impact of FLT3-ITD “macroclones” (allelic rati...
Chronic pain in sickle cell disease: a role for lysophosphatidic acid
Abstract Sickle cell disease (SCD) is a hereditary hemoglobinopathy characterized by persistent pain. The mechanisms underlying pain in SCD are poorly understood, and opioids remai...
Promises and potential pitfalls of in vivo CAR gene therapy
Abstract Genetically modified T cells expressing chimeric antigen receptors (CARs) manufactured ex vivo have demonstrated high efficacy in patients with lymphoid hematologic malign...
To deplete or not to deplete: that is the question
Neonatal platelets: MDSC-ooling the monocytes
Neonatal platelets differentiate monocytes to a myeloid-derived suppressor cell phenotype
Abstract Adult platelets are relatively enriched in immune-related molecules compared with neonatal platelets, but neonatal platelets express some growth factors and enzymes at com...
Domostegui A, Peddigari S, Mercer CA, et al. Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death. <i>Blood</i> . 2021;137(24):3351-3364.
Tunneling nanotube–mediated intercellular filamin A transport mechanosensitively programs osteoclastogenesis in myeloma bone disease
Abstract Intercellular communication between multiple myeloma (MM) cells and osteoclast precursor cells (pre-OCs) contributes extensively to the occurrence and development of myelo...
Lipids drive chronic sickle cell disease pain
Nanotube trafficking fuels myeloma bone loss
Epigenetic toggling between multipotency and differentiation
CD19 CAR T-cell therapy is feasible for patients with pemphigus vulgaris treated without lymphodepletion in the RESET-PV trial
Abstract Lymphodepleting preconditioning (LD) is essential for the efficacy of chimeric antigen receptor (CAR) T-cell therapy in hematologic malignancies. However, in the setting o...