Blood
Articles in this Issue
NOTCHing the MSC-endothelial interplay in the HSC niche
Procr+ endothelial progenitor cells govern hematopoiesis through fine-tuning mesenchymal stem cell niche signals
Abstract Hematopoietic stem cells (HSCs) rely on specialized niche cells for their maintenance, yet how these regulators functionally integrate to preserve hematopoiesis remains un...
Li C, Wu B, Li Y, et al. Loss of sphingosine kinase 2 promotes the expansion of hematopoietic stem cells by improving their metabolic fitness. <i>Blood</i> . 2022;140(15):1686-1701.
Haploidentical transplant, gene therapy, and standard care in sickle cell disease: a cost-effectiveness analysis
Abstract Nonmyeloablative-related haploidentical allogeneic stem cell transplantation (NMAC-HID allo-HSCT) has emerged as an additional treatment to achieve durable remission in si...
Granulopoiesis under attack by mutant IDH1
Abro B, Maurer MJ, Habermann TM, et al. Real-world impact of differences in the WHO and ICC classifications of non-Hodgkin lymphoma: a LEO cohort study analysis. <i>Blood</i> . 2024;144(19):2063-2066.
<i>IDH2</i> clonal hematopoiesis and IKAROS loss cooperate in a B-ALL subtype after lenalidomide therapy for multiple myeloma
Abstract Lenalidomide, a maintenance treatment in multiple myeloma first-line therapy, increases the risk of secondary malignancies, including B-cell precursor acute lymphoblastic...
Mutant IDH1 blocks neutropoiesis by repressing myeloid progenitor programs
Abstract IDH1 and IDH2 are frequently mutated in various cancers, including acute leukemias. However, the distinct mechanisms by which mutant IDH1 or IDH2 drive hematopoietic neopl...
IKAROS descent and rise of lenalidomide-associated B-ALL
Dissecting polycomb complexes for enhanced fetal hemoglobin production
Abstract Polycomb repressive complex 1 (PRC1) and PRC2 regulate diverse developmental processes, including the fetal-to-adult switch in hemoglobin (Hb) production, a process whose...
Precision targeting of fetal hemoglobin repressors
How I utilize somatic alterations in the diagnosis, risk stratification, and therapy of hypocellular bone marrow failure
Abstract Hypocellular bone marrow failure (BMF) may be acquired due to immune-mediated disease, the prototype being immune aplastic anemia (IAA), or inherited, due to germ line def...
Pound wise, penny foolish: improving value in SCD care
Anti-BCMA/GPRC5D CAR T cells in patients with relapsed or refractory multiple myeloma who have extraosseous extramedullary disease
Abstract Patients with relapsed or refractory multiple myeloma (RRMM) with extraosseous extramedullary disease (EMD) have inferior outcomes and lack effective therapies. We develop...
Bispecific CAR T for extramedullary myeloma: a minute waltz
Biosimilars approved for hematology use: lessons from comparative efficacy studies and comparative analytical assessments
Abstract Biosimilars used in hematology have been at the forefront of biosimilar development since the first US approval in 2015 of a filgrastim product, with &gt;80 now licens...
ELN-DAVID recommendations for NGS-based <i>FLT3</i> -ITD MRD testing for patients with acute myeloid leukemia
Abstract FLT3-internal tandem duplication measurable residual disease testing for patients in remission from acute myeloid leukemia is now recommended by the recently updated clini...