Blood
Articles in this Issue
Defusing AML: targeting t(8;21) forces myeloid maturation
Neutrophils fine-tune the NET effects of activation
Promyelocyte maturation arrest after rituximab-induced late-onset neutropenia mimicking acute promyelocytic leukemia
Fusion gene depletion eliminates stemness and induces bidirectional differentiation of acute myeloid leukemia
Abstract Chromosomal rearrangements that generate novel fusion genes are a hallmark of acute myeloid leukemia (AML). Depletion experiments in cell line models have suggested that t...
Platelet heterogeneity: variety makes immune and vascular function better
Abstract Platelets are dynamic cells that perform vital roles both in thrombosis and in immune regulation. Platelets are activated through well described signaling pathways after i...
Layilin: a novel regulator of platelet reactivity in IBD
CUX1 restrains latent hematopoietic stem cell plasticity by suppressing stem cell–intrinsic inflammatory pathways
Abstract Long-term maintenance of somatic stem cells relies on precise regulation of self-renewal and differentiation. Understanding the molecular framework for these homeostatic p...
Talquetamab plus daratumumab for the treatment of relapsed or refractory multiple myeloma in the TRIMM-2 study
Abstract Talquetamab, a G protein–coupled receptor class C group 5 member D–targeting bispecific antibody for relapsed/refractory multiple myeloma (R/R MM), plus daratumumab, may l...
Enhancing the targeting of the undruggable
Platelet heterogeneity in disease: the many and the diverse?
Abstract Platelets in peripheral blood critically drive clot formation in health and disease. Previously considered to uniformly respond to vascular injury and inflammatory cues, r...
Introduction to a review series on platelet heterogeneity
Beyond their role in hemostasis and thrombosis, platelets are now known to be important in inflammation, sepsis, cancer, and vascular integrity. Edited by Elisabeth M. Battinelli, this Review Series e...
Reprogramming glutamine metabolism enhances <i>BCMA</i> -CAR T-cell fitness and therapeutic efficacy in multiple myeloma
Abstract Glutamine dependence of cancer cells reduces local glutamine availability, which hinders antitumor T-cell functionality and facilitates immune evasion. We thus speculated...
Intestinal hepcidin overexpression promotes iron deficiency anemia and counteracts iron overload via DMT1 downregulation
Abstract Hepcidin is the key hyposideremic hormone produced primarily by the liver. However, recent reports reveal extrahepatic functional sources of hepcidin, including the intest...
Nuclear respiratory factor 1 promotes cell survival in multiple myeloma under proteasome inhibition therapy
Abstract Multiple myeloma (MM) continues to be an incurable malignancy, even with recent therapeutic advancements. Although epigenetic dysregulation at cis-regulatory elements is k...
Interplay of procoagulatory and neutrophil-derived anticoagulatory proteins in C1q-NET–driven blood coagulation
Abstract Neutrophils interact with the external milieu in both tissue and blood microenvironments and are emerging as important regulators of blood coagulation. In this study, we e...
Less CUX1, more retroelements: inflammation fuels stemness
Luminal hepcidin targets intestinal DMT1
Improving MM outcomes with bispecific antibody combinations
Clinical and research methods for analysis and study of platelet populations
Abstract Blood platelets are crucial in hemostasis, thrombosis, and thromboinflammation. Current evidence highlights the considerable heterogeneity within individuals in platelet s...
Glu(tamine)ing together myeloma metabolism and CAR T efficacy
Layilin inhibits integrin activation, and its loss results in platelet hyperactivation via Rac1 in inflammatory bowel disease
Abstract Platelets are specialized cells for hemostasis which circulate in close contact to the glycocalyx, an extracellular layer of interwoven glycoproteins, proteoglycans, and g...