Blood
Articles in this Issue
Global access to commercial CAR T-cell therapies: a cross-sectional study of health technology assessment across the G20 countries
Abstract Chimeric antigen receptor (CAR) T cells are a major treatment advance for many patients with hematological malignancies, especially those with disease that has relapsed or...
When estrogen sparks clotting: the lactoferrin-FXI link
Genomic mechanisms of resistance to venetoclax in multiple myeloma with t(11;14)( <i>CCND1</i> ; <i>IGH</i> )
Abstract Multiple myeloma (MM) with t(11;14)(CCND1;IGH) remains the only subset sensitive to the BCL2 inhibitor venetoclax. However, not all patients with t(11;14)(CCND1;IGH) respo...
Venetoclax in myeloma: t(11;14) and what else?
Ultraprecision therapy for type 1 vs type 2 CALR+ MPN by dual epitope targeting that restores ruxolitinib sensitivity
Abstract Somatic frameshift mutations in the gene encoding calreticulin (CALR) give rise to myelofibrosis and are classified as type 1 (del52) or type 2 (ins5) according to the deg...
SCD hemolysis aftershock: heme-IFN-CCL2 harms kidneys
Access to CAR T-cell therapy across diverse global markets
Breast hairy cell leukemia mimicking lobular breast carcinoma
Transient SP140 inhibition unlocks hematopoietic stem cell fate from human pluripotent stem cells
Abstract Efficient derivation of transplantable hematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) is constrained by epigenetic silencing. Through a clustere...
Estrogen upregulates lactoferrin to induce hypercoagulability for hemostatic protection during pregnancy
Abstract Venous thromboembolism (VTE) remains a leading contributor to maternal morbidity and mortality during pregnancy and the immediate postpartum period. Although pregnancy is...
Diagnosis and management of AML in pediatric patients: consensus recommendations from an international expert panel
Abstract The European LeukemiaNet has periodically issued guidelines for the diagnosis and management of acute myeloid leukemia (AML) in adults. These consensus recommendations, mo...
Metamizole-induced agranulocytosis resulting in ecthyma gangrenosum after an AI chatbot query
Arora J, Ayyappan S, Yin C, et al. T-cell help in the tumor microenvironment enhances rituximab-mediated NK-cell ADCC. <i>Blood</i> . 2024;143(18):1816-1824.
Turning off SP140 to turn on HSCs
Breaking new ground with antibody-drug conjugates in myeloma
Belantamab mafodotin, lenalidomide, and dexamethasone for intermediate-fit and frail patients with newly diagnosed myeloma
Abstract The phase 1/2 BelaRd (belantamab mafodotin [belamaf], lenalidomide, and dexamethasone) study evaluated the efficacy and safety of belamaf combined with lenalidomide and de...
Heme-induced activation of the TLR3/TRIF–IFN-I–CCL2 pathway contributes to kidney injury in sickle cell disease
Abstract Sickle cell nephropathy (SCN) is a major clinical complication in sickle cell disease (SCD), yet its underlying mechanisms remain incompletely defined. Hemolysis, a hallma...
Double trouble: dual-epitope targeting of mutant CALR
Chronic active Epstein-Barr virus disease: molecular pathogenesis, evolving concepts, and emerging therapies
Abstract Chronic active Epstein-Barr virus (EBV; CAEBV) disease is an uncommon, often lethal T and/or natural killer (T/NK)–cell lymphoproliferative disorder that remains underreco...