Blood
Articles in this Issue
Cracking the CODEX of the leukemic BM microenvironment
CSNK1E sustains stemlike drug persistence in diffuse large B-cell lymphoma
Abstract Relapsed or refractory (R/R) disease occurs in up to 40% of patients with diffuse large B-cell lymphoma (DLBCL) following first-line immunochemotherapy. However, the molec...
A reassessment of anti–CAR T-cell expansion strategies
Antigen-boosted CD4CAR T cells fail to expand or control viremia in multiple nonhuman primate models of HIV
Abstract Chimeric antigen receptor T (CAR T)-cell therapy has demonstrated curative potential in B-cell malignancies; yet, translating this success to chronic infections such as HI...
Morphologic and flow cytometric features of menin inhibitor–induced pseudoprogression in <i>KMT2A</i> -rearranged acute myeloid leukemia
The GATA1 N terminus coordinates metabolic reprogramming in erythropoiesis
Abstract Mutations in GATA1 that cause skipping of exon 2, which encodes the N terminus, are associated with the myeloid leukemia of Down syndrome and Diamond-Blackfan anemia (DBA)...
Unlocking the locking secret behind FNAlT
CD117-targeted HCT preconditioning in AML and MDS
How I treat HLH-like toxicities after immune effector cell therapy
Abstract Breakthroughs in cancer immunotherapy have redefined patient care, ushering in a new era of therapeutic modalities, chimeric antigen receptor T cells (CAR-T), and bispecif...
Thrombotic thrombocytopenic purpura: celebrating 25 years of ADAMTS13
Abstract Thrombotic thrombocytopenic purpura (TTP) was first described just over a century ago, and it is now 25 years since the identification of ADAMTS13 as the enzyme deficient...
Clusterin maintains hemostatic equilibrium by stabilizing VWF multimers in plasma
Abstract The coagulation-anticoagulation balance is tightly regulated by endothelial-derived factors, which have not been clearly defined. Here, we report that clusterin, a compone...
High-dimensional spatiotemporal single-cell atlas and 3D imaging of the bone marrow microenvironment during CML progression
Abstract The bone marrow microenvironment (BMME) is essential for hematopoiesis and immunity, yet spatiotemporal single-cell analysis during leukemogenesis remains challenging. We...
Structural basis of HPA-1a alloimmunization in FNAIT and allosteric regulation of integrin conformation
Abstract Fetal and neonatal alloimmune thrombocytopenia (FNAIT) can be caused by maternal immunoglobulin G alloantibodies against the human platelet antigen 1a (HPA-1a), a Leu33Pro...
Nonmyeloablative conditioning combined with the anti-CD117 antibody briquilimab in older adults with high-risk AML and MDS
Abstract Briquilimab is a monoclonal antibody inhibiting stem cell factor (SCF) binding to CD117 (c-Kit). Based on preclinical data demonstrating the antibody clears hematopoietic...