Blood
Articles in this Issue
CD5-positive high-grade B-cell lymphoma with <i>MYC</i>, <i>BCL2</i>, and <i>BCL6</i> rearrangements
Management of iron overload: lessons from transfusion-dependent hemoglobinopathies
Abstract Before the advent of effective iron chelation, death from iron-induced cardiomyopathy and endocrine failure occurred in the second decade in patients with thalassemia major,...
How I treat iron overload in adult MDS
Abstract Although clinical benefits of iron chelation therapy (ICT) in red blood cell (RBC) transfusion–dependent (TD) hereditary anemias such as α-thalassemia major are incontrovert...
Montoro J, Eikema D-J, Tuffnell J, et al. Alternative donor transplantation for severe aplastic anemia: a comparative study of the SAAWP EBMT. <i>Blood.</i> 2024;144(3):323-333.
Cryo-EM structure of the human native plasma coagulation factor XIII complex
Abstract The structure of human coagulation factor XIII (FXIII), a heterotetrameric plasma protransglutaminase that covalently cross-links preformed fibrin polymers, remains elusive...
Safety and efficacy of pegcetacoplan treatment for cold agglutinin disease and warm antibody autoimmune hemolytic anemia
Abstract Cold agglutinin disease (CAD) and warm antibody autoimmune hemolytic anemia (wAIHA) are rare autoimmune hemolytic anemias characterized by red blood cell destruction, largel...
Another cryo-EM success: structure of FXIII
IKZF1: born to be the repressor
Conserved helical motifs in the IKZF1 disordered region mediate NuRD interaction and transcriptional repression
Abstract The transcription factor (TF) Ikaros zinc finger 1 (IKZF1) is essential for B-cell development, and recurrently mutated in human B-cell acute lymphoblastic leukemia (B-ALL)....
How I manage iron overload in the hematopoietic cell transplantation setting
Abstract The success of hematopoietic transplantation for hemoglobinopathies and hematological malignancies has been accompanied by the new challenge of how to identify, risk stratif...
Inflammatory Waldenström macroglobulinemia is associated with clonal hematopoiesis: a multicentric cohort
Abstract Inflammatory form of Waldenström macroglobulinemia (iWM) predicts outcomes after immuno-chemotherapy and Bruton tyrosine kinase inhibitors, but its origin is unknown. Here,...
Ex vivo venetoclax sensitivity predicts clinical response in acute myeloid leukemia in the prospective VenEx trial
Abstract The B-cell lymphoma 2 inhibitor venetoclax has shown promise for treating acute myeloid leukemia (AML). However, identifying patients likely to respond remains a challenge,...
VenEx precisely predicts ven-aza response
“Complementing” hemolytic anemias: what’s next?
Introduction to a How I Treat series on iron overload in hematologic disorders
It has long been recognized that iron overload is toxic and that diagnosis and management of iron overload in patients with hematological disorders are complex and can be disease-specific. Associate E...