Blood
Articles in this Issue
International consensus statement on diagnosis, evaluation, and research of Richter transformation: the ERIC recommendations
Abstract Richter transformation (RT) is defined as an aggressive lymphoma emerging in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL). Despite novel thera...
Platelet NLRP6: a hidden talent?
Clinical phenotype and pathophysiological mechanisms underlying qualitative low VWF
Abstract Previous reports have highlighted that some patients with low von Willebrand factor (VWF) with significant bleeding were diagnosed based on an isolated but persistent reduct...
PROTACtion against BCL-xL in post-MPN AML
Secondary blastoid plasma cell leukemia: can an old dog learn new tricks?
An unbiased genomewide screen uncovers 7 genes that drive hematopoietic stem cell fate from mouse embryonic stem cells
Abstract Hematopoietic stem cells (HSCs) possess the ability to long term reconstitute all the blood lineages and generate all blood cell types. As such, the in vitro generation of H...
Duployez N, Largeaud L, Duchmann M, et al. Prognostic impact of <i>DDX41</i> germline mutations in intensively treated acute myeloid leukemia patients: an ALFA-FILO study. <i>Blood</i>. 2022;140(7):756-768.
m6A meets T-ALL: HNRNPC and FTO as new therapeutic targets
Type 1 von Willebrand disease: does it need a sibling?
Epigenetic drug remedies for SCD root cause pathophysiology
Weathering the HLH storm and redesigning clinical trials
Efficacy of a novel BCL-xL degrader, DT2216, in preclinical models of <i>JAK2</i>-mutated post-MPN AML
Abstract Acute myeloid leukemia (AML) that evolves from myeloproliferative neoplasm (MPN) is known as post-MPN AML. Current treatments do not significantly extend survival beyond 12...
Richter transformation recommendations
Qualitative low VWF
Novel, potent, and orally bioavailable LSD1 inhibitors induce fetal hemoglobin synthesis in a sickle cell disease mouse model
Abstract Small molecules that inhibit LSD1 (lysine-specific demethylase 1, KDM1A) have been shown to induce abundant fetal hemoglobin (HbF) levels in red blood cells both in vitro an...
Ruxolitinib combined with dexamethasone for adult patients with newly diagnosed hemophagocytic lymphohistiocytosis in China
Abstract Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome, and the overall survival (OS) of adult patients is poor. Ruxolitinib, a Janus kinase 1/2 (JA...
Unusual suspects: a surprise cast in making blood stem cells
HNRNPC and m6A RNA methylation control oncogenic transcription and metabolism in T-cell leukemia
Abstract RNA homeostasis is dysregulated in cancer and affects disease progression and therapy resistance. N6-methyladenosine (m6A), the most abundant epitranscriptomic modification...
Proteostasis disruption in inherited bone marrow failure syndromes
Abstract Inherited bone marrow failure syndromes (IBMFS) are genetic disorders of impaired hematopoiesis that manifest in childhood with both cytopenias and extrahematologic findings...
Platelet NLRP6 protects against microvascular thrombosis in sepsis
Abstract Sepsis is characterized by a systemic inflammation and microvascular thrombosis induced by infection. The nucleotide-oligomerization domain–like receptor family pyrin domain...