Blood
Articles in this Issue
How I treat higher-risk MDS
Abstract Myelodysplastic syndromes/neoplasms (MDS) are a widely heterogenous group of myeloid malignancies characterized by morphological dysplasia, a defective hematopoiesis, and re...
Breathing life into the hematopoietic potential of the lung
Is β2-glycoprotein I prothrombotic?
NETs persisting in vasculature undergo self-renewal with consequences for subsequent infection: a mouse model study
Abstract Although key for pathogen immobilization, neutrophil extracellular traps (NETs) often cause severe bystander cell/tissue damage. This was hypothesized to depend on their pro...
NET self-renewal: vascular Groundhog Day
Decoding functional hematopoietic progenitor cells in the adult human lung
Abstract Although the bone marrow is the main site of blood cell production in adults, rare pools of hematopoietic stem and progenitor cells have been found in extramedullary organs....
Microbiota drives colitis in chronic granulomatous disorder
Long-term outcomes with single-agent BRAF inhibitor therapy in Erdheim-Chester disease
Abstract Among 64 patients with Erdheim-Chester disease treated with a BRAF inhibitor (median follow-up 4 years), we found high response rates (85%) but frequent discontinuations (61...
Donor regulatory T-cell therapy to prevent graft-versus-host disease
Abstract Allogeneic hematopoietic cell transplantation is a curative therapy limited by graft-versus-host disease (GVHD). In preclinical studies and early-phase clinical studies, enr...
Mixed-phenotype acute leukemia revisited: omics lead the way
When lymphoma mimics adenocarcinoma: signet ring morphology in follicular lymphoma
Reactive oxygen species regulate early development of the intestinal macrophage-microbiome interface
Abstract The controlled development of cellular intestinal immunity in the face of dynamic microbiota emergence constitutes a major challenge in very early life and is a bottleneck f...
Defining 2 biologically and clinically distinct groups in acute leukemia with a mixed phenotype
Abstract A mixed phenotype (MP) is a characteristic of de novo MP acute leukemia (MPAL), but it can also be found in other leukemias. It poses substantial classification and manageme...
Protection of β2GPI-deficient mice from thrombosis reflects a defect in PAR3-facilitated platelet activation
Abstract Antibodies to β2-glycoprotein I (β2GPI) cause thrombosis in antiphospholipid syndrome; however, the role of β2GPI in coagulation in vivo is not understood. To address this...
Class struggle in DLBCL
DLB<i>class</i>: a probabilistic molecular classifier to guide clinical investigation and practice in diffuse large B-cell lymphoma
Abstract Diffuse large B-cell lymphoma (DLBCL) is a clinically and molecularly heterogeneous disease. The increasing recognition and targeting of genetically defined DLBCLs highlight...
Donor regulatory/conventional T-cell grafts for the GVHD win?
Clinical-genomic profiling of MDS to inform allo-HCT: recommendations from an international panel on behalf of the EBMT
Abstract For patients with myelodysplastic neoplasm/syndrome (MDS), allogeneic hematopoietic cell transplantation (allo-HCT) represents the only potentially curative treatment, capab...