Blood
Articles in this Issue
Das not enough in CBF AML
Clonal hematopoiesis and lymphoma-associated mutations in hematopoietic progenitors in B-cell non-Hodgkin lymphoma
Abstract The contribution of clonal hematopoiesis (CH) and disease-initiating precursors in B-cell non-Hodgkin lymphomas (B-NHLs) remains underexplored. Such precursors may drive c...
Digging deep for the roots of lymphoma
Targeted therapy in early-stage classical Hodgkin lymphoma
Rescue gone rogue: the ERCC6L2 syndrome and TP53 mutations
Li S, Pal R, Monaghan SA, et al. IMiD immunomodulatory compounds block C/EBPβ translation through eIF4E down-regulation resulting in inhibition of MM. <i>Blood</i> . 2011;117(19):5157-5165.
Bone marrow failure, somatic rescue by p53 inactivation, and enhanced leukemogenesis in germ line ERCC6L2 disease
Abstract Recessively inherited loss-of-function mutations in excision repair cross-complementing 6–like 2 (ERCC6L2) cause a bone marrow failure (BMF) syndrome characterized by mode...
A phase 3 study of intensive chemotherapy with or without dasatinib in core-binding factor acute myeloid leukemia
Abstract Core-binding factor acute myeloid leukemia (CBF-AML) is associated with KIT mutations and deregulated expression of KIT. We report results from the randomized, open-label,...
Ibrutinib: 10 years and counting
Ring of fire cells: plasma cell–predominant relapse of Waldenström macroglobulinemia
Charting human developmental hematopoiesis in vitro to open new routes for regenerative medicine
Abstract The hematopoietic system performs essential functions for living organisms through a wide array of cell types, including immune cells for host defense, erythrocytes for ox...
CML mimicker: a myeloid neoplasm with <i>BCR</i> :: <i>FGFR1</i> fusion without peripheral blood eosinophilia or basophilia
Heating up coagulation through necroptosis
GVHD fails the acid test
Gastrin for the treatment of acute graft-versus-host disease of the stomach
Abstract Acute graft-versus-host disease (aGVHD) is a major cause of death after allogeneic hematopoietic cell transplantation, and patients with steroid-refractory aGVHD have a di...
How I approach clinical ethics consultation in hematology
Abstract Caring for individuals with hematologic disorders is increasingly complex, and with medical complexity often comes ethical complexity. Prognostic uncertainty, stakeholder...
Brentuximab vedotin and nivolumab in combination with chemotherapy for nonbulky, early-stage classical Hodgkin lymphoma
Abstract Most patients with early-stage classical Hodgkin lymphoma (cHL) are treated with doxorubicin, bleomycin, vinblastine, and dacarbazine with or without radiation therapy, al...
A decade of ibrutinib for CLL with and without <i>TP53</i> aberration: final report on an investigator-sponsored phase 2 study
Abstract Bruton tyrosine kinase inhibitors improve outcomes for patients with chronic lymphocytic leukemia (CLL). Long-term data with continuous therapy are limited. With a median...
Heat stress activates the coagulation cascade through Z-DNA-binding protein 1–dependent necroptosis
Abstract Heatstroke, a severe hyperthermic condition, is characterized by a core body temperature &gt;40°C and multiple organ dysfunction syndrome (MODS), with an extremely hig...