Blood
Articles in this Issue
Chakraborty R, Brailovsky Y, Hanna M, et al. Prognostic factors and progression biomarkers in AL amyloidosis: mapping current knowledge and critical gaps. <i>Blood</i> . 2026;147(21):2448-2462.
Platelet-derived TGF-β1 and Treg maintenance in a murine model of ITP
Abstract Studies suggest that platelet-derived transforming growth factor (TGF)-β1 is critical to immune thrombocytopenia tolerance via regulatory T-cell (Treg) modulation, but the...
MDM4 haploinsufficiency leads to p53-mediated bone marrow failure
Abstract Bone marrow failure (BMF) syndromes are heterogeneous diseases characterized by impaired hematopoiesis and a risk of evolution to myelodysplastic syndrome (MDS) and leukem...
Platelet TGF-β and Tregs in ITP: going steady or breaking up?
FLT3-ITD scaffolds PKCι-STAT1 to drive noncanonical S727 phosphorylation and CD276-driven CD8+ T-cell exhaustion in AML
Abstract The internal tandem duplications in FMS-like tyrosine kinase 3 (FLT3-ITD) are associated with poor prognosis in acute myeloid leukemia (AML), yet its kinase-independent me...
Fibrin as a thrombin sink: a factor retaining a thrombus in the stillness phase
Abstract The process of nonocclusive thrombus formation is well known, but the mechanism keeping the thrombus silent at the end stage remains unclear. The aim of this work was to e...
Soiffer RJ. Graft manipulation and GVHD: what goes around comes around. <i>Blood</i> . 2026;147(11):1137-1138.
A phase 1/1b study of the BCMA-targeting bispecific T-cell engager pavurutamab for relapsed/refractory multiple myeloma
Abstract The B-cell maturation antigen (BCMA)–targeting bispecific T-cell engager pavurutamab (AMG 701) directs the cytotoxic T-cell response toward multiple myeloma (MM) cells. Th...
An emerging family of bone marrow failure syndromes
The rapidly evolving BCMA landscape in multiple myeloma
Fibrin is a thrombin sink that leads to stillness of thrombi
Chasing uncertain significance in <i>PIEZO1</i> variants
CNS relapse during menin inhibitor therapy
Refined classification and phenotype-driven analysis of <i>PIEZO1</i> variants in hereditary red blood cell and iron disorders
Abstract Interpreting genetic variants in complex genes such as PIEZO1 remains challenging because of marked allelic heterogeneity, relative tolerance to missense variation, and ov...
Beyond kinase activity: FLT3-ITD scaffolds immune escape
Neutrophils as chameleons of tissue inflammation and host-pathogen interactions
Abstract Neutrophils are acute responders to bacterial and fungal infection; however, their roles in disease extend far beyond their critical roles in countering pathogens. In this...
Unfinished business in chronic lymphocytic leukemia: translational and clinical priorities for a cure
Abstract Remarkable progress in the understanding of disease pathogenesis and treatment across hematologic malignancies has been achieved in the past 2 decades. Nevertheless, the r...