Blood
Articles in this Issue
Postimmunotherapy lineage switch: where to from here?
NKG2D-mediated cytotoxicity of CD4 cytotoxic T cells in multiple myeloma
Abstract Emerging evidence indicates that CD4+ T cells contribute to antitumor immunity beyond their traditional roles as helpers or regulators. However, the specific subset of CD4+...
Relationship between immunogenicity and protein structure at amino acid substitution sites of blood group antigens
Abstract Polypeptide blood group antigens, many of which are created by single exofacial amino acid substitutions, have varying immunogenicities. Why some amino acid substitutions ar...
Differentiation-dependent EBF1 activity determines <i>CD22</i> transcription and leukemia sensitivity to inotuzumab ozogamicin
Abstract Inotuzumab ozogamicin (InO) is an antibody-calicheamicin conjugate with high efficacy in lymphoid malignancies. It targets the B-cell surface protein CD22, which is expresse...
Predicting blood group antigens: accessible or not?
Inhibiting JAK1: lowering CRS, CAR stays on track
Shear-dependent platelet aggregation by ChAdOx1 nCoV-19 vaccine: a novel biophysical mechanism for arterial thrombosis
Abstract Rare thrombotic events associated with ChAdOx1 nCoV-19 (ChAdOx1) vaccination have raised concerns; however, the underlying mechanisms remain elusive. Here, we report a novel...
Cytolytic helper T cells: a new addition to myeloma immunity
Itacitinib for the prevention of IEC therapy–associated CRS: results from the 2-part phase 2 INCB 39110-211 study
Abstract Cytokine release syndrome (CRS) and immune effector cell (IEC)–associated neurotoxicity syndrome (ICANS) are common complications after IEC therapy for hematologic malignanc...
Dissecting JAK2V617F’s double life with and without MPL
Breakthrough hemolysis in paroxysmal nocturnal hemoglobinuria throughout clinical trials: from definition to clinical practice
Abstract Breakthrough hemolysis (BTH) is the hemolytic exacerbation occurring in a patient with paroxysmal nocturnal hemoglobinuria (PNH) on treatment with anticomplement therapies....
Project EVOLVE: an international analysis of postimmunotherapy lineage switch, an emergent form of relapse in leukemia
Abstract Lineage switch (LS), defined as the immunophenotypic transformation of acute leukemia, has emerged as a mechanism of relapse after antigen-targeted immunotherapy, which is a...
Hematological aspects of colchicine poisoning
Delineating <i>Mpl</i>-dependent and -independent phenotypes of <i>Jak2</i> V617F–positive MPNs in vivo
Abstract The Jak2 V617F mutation stands as the main driver of myeloproliferative neoplasms (MPNs) by constitutively activating signaling through several type I cytokine receptors, na...