Blood
Articles in this Issue
A novel way for transglutaminase 2 to mitigate liver damage
Integrative genomic analysis of DLBCL identifies immune environments associated with bispecific antibody response
Abstract Most patients with diffuse large B-cell lymphoma (DLBCL) treated with immunotherapies such as bispecific antibodies (BsAbs) or chimeric antigen receptor (CAR) T cells fail t...
Inflammation conjoins differentiation and resistance in AML
Immunotherapy response: is it all in the DLBCL-IQs?
How I approach pharmacological thromboprophylaxis in children
Abstract The incidence of venous thromboembolism in children continues to rise, with the most recent analysis from the Pediatric Hospital Information Systems database in the United S...
Haploidentical HSCT: more curative options for patients with CGD
Chromatin dynamics in CLL: a matter of balance
Clonal hematopoiesis landscape in frequent blood donors
Abstract Donor blood saves lives, yet the potential impact of recurrent large-volume phlebotomy on donor health and hematopoietic stem cells (HSCs) remains largely unexplored. In our...
A CEBPB/IL-1β/TNF-α feedback loop drives drug resistance to venetoclax and MDM2 inhibitors in monocytic leukemia
Abstrat MDM2 inhibitors are promising therapeutics for acute myeloid leukemia (AML) with wild-type TP53. Through an integrated analysis of functional genomic data from primary patien...
Lymphoid malignancies in patients with Shwachman-Diamond syndrome
Abstract This study identified an increased risk of lymphoid malignancy in Shwachman-Diamond syndrome (SDS) with an observed risk 38-fold higher than expected based on population dat...
Integrated cross-linking by TG2 and FXIII generates hepatoprotective fibrin(ogen) deposits in injured liver
Abstract The transglutaminase coagulation factor XIII (FXIII) is critical for the stability and function of intravascular fibrin clots. Prorepair extravascular fibrin(ogen) deposits...
Advances in RNA editing in hematopoiesis and associated malignancies
Abstract Adenosine-to-inosine (A-to-I) RNA editing is a prevalent RNA modification essential for cell survival. The process is catalyzed by the adenosine deaminase acting on RNA (ADA...
Classic hairy cell leukemia and concomitant smoldering myeloma
Blitzing ALL with blinatumomab
HLA-haploidentical stem cell transplantation for chronic granulomatous disease: an EBMT-IEWP retrospective study
Abstract Chronic granulomatous disease (CGD) is an inborn error of immunity characterized by defective NAD phosphate oxidase function, leading to impaired microbial killing, recurren...
Of donors and dynamics
Up-front blinatumomab improves MRD clearance and outcome in adult Ph– B-lineage ALL: the GIMEMA LAL2317 phase 2 study
Abstract The Gruppo Italiano Malattie EMatologiche dell’Adulto (GIMEMA) Leucemia Acuta Linfoblastica (LAL) 2317 protocol investigated the frontline chemotherapy-blinatumomab combinat...
Dual biological role and clinical impact of de novo chromatin activation in chronic lymphocytic leukemia
Abstract Previous studies have reported that chronic lymphocytic leukemia (CLL) shows a de novo chromatin activation pattern compared with normal B cells. Here, we explored whether t...