Blood
Articles in this Issue
Proteomics: the key to understanding AML hematopoietic aging
Death receptor 3 gives life to Tregs in GVHD
<i>FLI1</i> -related thrombocytopenia: piecing together the story
A prime editing strategy to rewrite the γ-globin promoters and reactivate fetal hemoglobin for sickle cell disease
Abstract Fetal hemoglobin reactivation is a promising therapy for β-hemoglobinopathies. We developed a prime editing strategy that introduces multiple mutations in the fetal γ-glob...
Above the cut: HbF induction by multiplex prime editing
Fixed-duration epcoritamab plus R2 drives favorable outcomes in relapsed or refractory follicular lymphoma
Abstract Epcoritamab is a subcutaneous CD3×CD20 bispecific antibody approved as monotherapy for relapsed/refractory (R/R) follicular lymphoma (FL). We evaluated fixed-duration epco...
Improved diagnostic screening and classification of clonal mast cell diseases by ultrasensitive <i>KIT</i> p.D816V detection
Abstract Detection of KIT p.D816V is a cornerstone in the diagnosis and classification of mast cell activation syndromes (MCAS) and mastocytosis. However, KIT p.D816V may be undete...
Old but gold: ILC-induced T-cell senescence prevents GVHD
Pretransplant targeting of TNFRSF25 and CD25 stimulates recipient Tregs in target tissues, ameliorating GVHD post-HSCT
Abstract The current approach to minimize transplant-associated complications, including graft-versus-host disease (GVHD) includes long-term pharmacological immune suppression freq...
MASTering <i>KIT</i> : enhanced sensitivity for refined diagnosis
Challenging the concept of functional high-risk myeloma through transcriptional and genetic profiling
Abstract Functional high-risk (FHR) multiple myeloma (MM) is defined as an unexpected, early relapse (ER) of disease in the absence of baseline molecular or clinical risk factors (...
Yeung DT, Shanmuganathan N, Reynolds J, et al; Australasian Leukaemia and Lymphoma Group. Asciminib monotherapy as frontline treatment of chronic-phase chronic myeloid leukemia: results from the ASCEND study. <i>Blood.</i> 2024;144(19):1993-2001.
Proteomic subtypes enrich current acute myeloid leukemia nomenclature and reflect intrinsic pathogenesis alongside aging
Abstract Acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy that increasingly affects the older population, with its posttranscriptional landscape rema...
Better together: epcoritamab boosts R2 in FL
Innate lymphoid cells prevent graft-versus-host disease via IL-9–driven T-cell senescence
Abstract Innate lymphoid cells (ILCs) are tissue-resident lymphocytes that regulate tissue homeostasis and immune responses. How ILCs modulate T cells, remains incompletely underst...